Primary Site >> Colorectal Cancer
Gene >> APAF1
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Ref: The dependence receptor DCC (deleted in colorectal cancer) defines an alternative mechanism for caspase activation. PMID: 11248093 Ref: TUCAN, an antiapoptotic caspase-associated recruitment domain family protein overexpressed in cancer. PMID: 11408476 Ref: Frameshift mutations at mononucleotide repeats in RAD50 recombinational DNA repair gene in colorectal cancers with microsatellite instability. PMID: 11429044 |
Ref: Molecular mechanism of gossypol-induced cell growth inhibition and cell death of HT-29 human colon carcinoma cells. PMID: 12818369 |
Ref: Tocotrienol-rich fraction of palm oil activates p53, modulates Bax/Bcl2 ratio and induces apoptosis independent of cell cycle association. PMID: 14712090 Ref: Allelic imbalance of APAF-1 locus at 12q23 is related to progression of colorectal carcinoma. PMID: 15378005 |
Ref: The proteasome inhibitor bortezomib sensitizes cells to killing by death receptor ligand TRAIL via BH3-only proteins Bik and Bim. PMID: 15767553 Ref: A predictive model of rectal tumor response to preoperative radiotherapy using classification and regression tree methods. PMID: 16061859 Ref: Analysis of apoptosis protein expression in early-stage colorectal cancer suggests opportunities for new prognostic biomarkers. PMID: 16061861 |
Ref: Scoring of p53, VEGF, Bcl-2 and APAF-1 immunohistochemistry and interobserver reliability in colorectal cancer. PMID: 16741523 |
Ref: Cimetidine induces apoptosis of human salivary gland tumor cells. PMID: 17273750 Ref: Loss of APAF-1 expression is associated with tumour progression and adverse prognosis in colorectal cancer. PMID: 17350821 Ref: Role of APAF-1, E-cadherin and peritumoral lymphocytic infiltration in tumour budding in colorectal cancer. PMID: 17516584 Ref: Modification of gene products involved in resistance to apoptosis in metastatic colon cancer cells: roles of Fas, Apaf-1, NFkappaB, IAPs, Smac/DIABLO, and AIF. PMID: 17603079 Ref: Apaf-1 Deficiency Causes Chromosomal Instability. PMID: 18073531 |
Ref: Combined analysis of VEGF and EGFR predicts complete tumour response in rectal cancer treated with preoperative radiotherapy. PMID: 18182986 Ref: An inactivating mutation in HDAC2 leads to dysregulation of apoptosis mediated by APAF1. PMID: 18834886 Ref: Two-marker protein profile predicts poor prognosis in patients with early rectal cancer. PMID: 18985041 |
Ref: Biphasic regulation of cell death and survival by hydrophobic bile acids in HCT116 cells. PMID: 19373611 Ref: RACK1 downregulates levels of the pro-apoptotic protein Fem1b in apoptosis-resistant colon cancer cells. PMID: 19855191 |
Ref: Urokinase-type plasminogen activator is a marker of aggressive phenotype and an independent prognostic factor in mismatch repair-proficient colorectal cancer. PMID: 19740518 Ref: Fem1b, a proapoptotic protein, mediates proteasome inhibitor-induced apoptosis of human colon cancer cells. PMID: 19908242 Ref: Expression and prognostic significance of APAF-1, caspase-8 and caspase-9 in stage II/III colon carcinoma: caspase-8 and caspase-9 is associated with poor prognosis. PMID: 20013803 Ref: Modulation of inflammatory changes in early stages of colon cancer through activation of PPARgamma by diclofenac. PMID: 20485182 Ref: Expression of p16 in lymph node metastases of adjuvantly treated stage III colorectal cancer patients identifies poor prognostic subgroups: a retrospective analysis of biomarkers in matched primary tumor and lymph node metastases. PMID: 20572035 Ref: Allyl isothiocyanate triggers G2/M phase arrest and apoptosis in human brain malignant glioma GBM 8401 cells through a mitochondria-dependent pathway. PMID: 20596632 Ref: Characterization of rectal, proximal and distal colon cancers based on clinicopathological, molecular and protein profiles. PMID: 20664940 Ref: Systematic assessment of protein phenotypes characterizing high-grade tumour budding in mismatch repair-proficient colorectal cancer. PMID: 20716165 Ref: Houttuynia cordata Thunb extract inhibits cell growth and induces apoptosis in human primary colorectal cancer cells. PMID: 20944136 |
Ref: Chemopreventive effects of non-steroidal anti-inflammatory drugs in early neoplasm of experimental colorectal cancer: an apoptosome study. PMID: 20623380 Ref: Loss of E-cadherin independently predicts the lymph node status in colorectal cancer. PMID: 21233674 Ref: Intracellular pH and calcium signaling as molecular targets of diclofenac-induced apoptosis against colon cancer. PMID: 21427588 Ref: Systematic analysis of proteins from different signaling pathways in the tumor center and the invasive front of colorectal cancer. PMID: 21664646 |
Ref: PNAS-4 expression and its relationship to p53 in colorectal cancer. PMID: 21556770 Ref: The use of molecular markers as a method to predict the response to neoadjuvant therapy for advanced stage rectal adenocarcinoma. PMID: 21689364 Ref: Stool-fermented Plantago ovata husk induces apoptosis in colorectal cancer cells independently of molecular phenotype. PMID: 22018732 Ref: Clinical application of a systems model of apoptosis execution for the prediction of colorectal cancer therapy responses and personalisation of therapy. PMID: 22082587 Ref: Piroxicam and C-phycocyanin mediated apoptosis in 1,2-dimethylhydrazine dihydrochloride induced colon carcinogenesis: exploring the mitochondrial pathway. PMID: 22369161 Ref: Apoptosome-dependent caspase activation proteins as prognostic markers in Stage II and III colorectal cancer. PMID: 22481083 Ref: Ursodeoxycholic acid protects colon cancer HCT116 cells from deoxycholic acid-induced apoptosis by inhibiting apoptosome formation. PMID: 22497644 Ref: Preferential killing of p53-deficient cancer cells by reversine. PMID: 22592527 Ref: Diallyl trisulfide induces apoptosis in human primary colorectal cancer cells. PMID: 22736270 |
Ref: Tautomycetin induces apoptosis by inactivating Akt through a PP1-independent signaling pathway in human breast cancer cells. PMID: 23269238 Ref: Daidzein causes cytochrome c-mediated apoptosis via the Bcl-2 family in human hepatic cancer cells. PMID: 23959101 Ref: Different susceptibility of colon cancer DLD-1 and LOVO cell lines to apoptosis induced by DMU-212, a synthetic resveratrol analogue. PMID: 24055891 |
Ref: The fermented non-digestible fraction of common bean (Phaseolus vulgaris L.) triggers cell cycle arrest and apoptosis in human colon adenocarcinoma cells. PMID: 24293398 Ref: The involvement of miR-23a/APAF1 regulation axis in colorectal cancer. PMID: 24992592 Ref: DNA methylation of apoptosis genes in rectal cancer predicts patient survival and tumor recurrence. PMID: 25064172 |
Ref: Predictive markers of response to neoadjuvant therapy in rectal cancer. PMID: 25481527 Ref: Regional Bias of Intratumoral Genetic Heterogeneity of Apoptosis-Related Genes BAX, APAF1, and FLASH in Colon Cancers with High Microsatellite Instability. PMID: 25599959 Ref: Induction of apoptosis in HCT-116 colon cancer cells by polysaccharide of Larimichthys crocea swim bladder. PMID: 25624917 Ref: Gambogic acid induces apoptosis and inhibits colorectal tumor growth via mitochondrial pathways. PMID: 26034354 Ref: A-kinase anchor protein 4 (AKAP4) a promising therapeutic target of colorectal cancer. PMID: 26590805 Ref: Changes in immunoexpression of p53, Ki-67, Ets-1, APAF-1 and PTEN in serrated and conventional colon adenomas. PMID: 26743285 |
Ref: DNA methylation based biomarkers in colorectal cancer: A systematic review. PMID: 27385266 Ref: Loss of APAF-1 expression is associated with early recurrence in stage I, II, and III colorectal cancer. PMID: 27480415 Ref: Methylferulate from Tamarix aucheriana inhibits growth and enhances chemosensitivity of human colorectal cancer cells: possible mechanism of action. PMID: 27716288 |
Ref: Anti-Cancerous Potential of Polysaccharide Fractions Extracted from Peony Seed Dreg on Various Human Cancer Cell Lines Via Cell Cycle Arrest and Apoptosis. PMID: 28316571 Ref: Knockdown of miR-27a sensitizes colorectal cancer stem cells to TRAIL by promoting the formation of Apaf-1-caspase-9 complex. PMID: 28423356 Ref: Libidibia ferrea presents antiproliferative, apoptotic and antioxidant effects in a colorectal cancer cell line. PMID: 28586741 Ref: A prognostic mutation panel for predicting cancer recurrence in stages II and III colorectal cancer. PMID: 28767131 Ref: In vitro investigation of the effect of matrix molecules on the behavior of colon cancer cells under the effect of geldanamycin derivative. PMID: 29034805 Ref: Inhibitory effect of hyperoside isolated from Zanthoxylum bungeanum leaves on SW620 human colorectal cancer cells via induction of the p53 signaling pathway and apoptosis. PMID: 29067453 |
Ref: Tunicamycin inhibits colon carcinoma growth and aggressiveness via modulation of the ERK-JNK-mediated AKT/mTOR signaling pathway. PMID: 29344654 |