Primary Site >> Colorectal Cancer

Gene >> ANAPC1

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Ref: A urochordate putative homolog of human EB1, the protein which binds APC1.
PMID: 9020915
Ref: Drosophila Apc1 and Apc2 regulate Wingless transduction throughout development.
PMID: 11923210
Ref: APC as a master regulator of intestinal homeostasis and transformation: from flies to vertebrates.
PMID: 19657225
Ref: [Effect of recombinant pEGFP-N3-APC vectors carrying various APC functional domains on the expression of beta-catenin in HT-29 cells].
PMID: 20197613
Ref: Non-autonomous crosstalk between the Jak/Stat and Egfr pathways mediates Apc1-driven intestinal stem cell hyperplasia in the Drosophila adult midgut.
PMID: 23172913
Ref: The Poly(ADP-ribose) Polymerase Enzyme Tankyrase Antagonizes Activity of the beta-Catenin Destruction Complex through ADP-ribosylation of Axin and APC2.
PMID: 27068743
Ref: Intestinal stem cell overproliferation resulting from inactivation of the APC tumor suppressor requires the transcription cofactors Earthbound and Erect wing.
PMID: 28708826
Ref: DNA damage response genes mark the early transition from colitis to neoplasia in colitis-associated colon cancer.
PMID: 30121380