Primary Site >> Colorectal Cancer
Gene >> ABCG2
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Ref: Molecular cloning of cDNAs which are highly overexpressed in mitoxantrone-resistant cells: demonstration of homology to ABC transport genes. PMID: 9892175 Ref: Atypical multidrug resistance: breast cancer resistance protein messenger RNA expression in mitoxantrone-selected cell lines. PMID: 10070941 Ref: Camptothecin resistance: role of the ATP-binding cassette (ABC), mitoxantrone-resistance half-transporter (MXR), and potential for glucuronidation in MXR-expressing cells. PMID: 10606239 |
Ref: The HER tyrosine kinase inhibitor CI1033 enhances cytotoxicity of 7-ethyl-10-hydroxycamptothecin and topotecan by inhibiting breast cancer resistance protein-mediated drug efflux. PMID: 11212277 Ref: Identification of breast cancer resistant protein/mitoxantrone resistance/placenta-specific, ATP-binding cassette transporter as a transporter of NB-506 and J-107088, topoisomerase I inhibitors with an indolocarbazole structure. PMID: 11306452 |
Ref: Carboxylesterase-mediated sensitization of human tumor cells to CPT-11 cannot override ABCG2-mediated drug resistance. PMID: 12869632 |
Ref: Subcellular localization of the camptothecin analogues, topotecan and gimatecan. PMID: 15006540 Ref: ABCG2 overexpression in colon cancer cells resistant to SN38 and in irinotecan-treated metastases. PMID: 15027118 Ref: Gefitinib reverses breast cancer resistance protein-mediated drug resistance. PMID: 15367706 Ref: Topoisomerase I inhibitors in the treatment of gastrointestinal cancer: from intravenous to oral administration. PMID: 15377400 |
Ref: Unfavourable expression of pharmacologic markers in mucinous colorectal cancer. PMID: 15655543 Ref: Gene expression profiling in chemoresistant variants of three cell lines of different origin. PMID: 16080509 Ref: The epidermal growth factor receptor tyrosine kinase inhibitor gefitinib sensitizes colon cancer cells to irinotecan. PMID: 16222152 Ref: Piperazinobenzopyranones and phenalkylaminobenzopyranones: potent inhibitors of breast cancer resistance protein (ABCG2). PMID: 16279786 |
Ref: Role of pharmacogenetics in irinotecan therapy. PMID: 16343744 Ref: Modulation of p-glycoprotein and breast cancer resistance protein by some prescribed corticosteroids. PMID: 16442095 Ref: Disposition of 9-nitrocamptothecin and its 9-aminocamptothecin metabolite in relation to ABC transporter genotypes. PMID: 16505951 Ref: Down-regulation of BCRP/ABCG2 in colorectal and cervical cancer. PMID: 16554028 Ref: Prolonged exposure of colon cancer cells to the epidermal growth factor receptor inhibitor gefitinib (Iressa(TM)) and to the antiangiogenic agent ZD6474: Cytotoxic and biomolecular effects. PMID: 16937523 |
Ref: TTI-237: a novel microtubule-active compound with in vivo antitumor activity. PMID: 18381436 Ref: Single-step doxorubicin-selected cancer cells overexpress the ABCG2 drug transporter through epigenetic changes. PMID: 18382425 Ref: Regulation of ABCG2 expression at the 3' untranslated region of its mRNA through modulation of transcript stability and protein translation by a putative microRNA in the S1 colon cancer cell line. PMID: 18573883 Ref: Folate deprivation induces BCRP (ABCG2) expression and mitoxantrone resistance in Caco-2 cells. PMID: 18623116 Ref: A gene-wide investigation on polymorphisms in the ABCG2/BRCP transporter and susceptibility to colorectal cancer. PMID: 18775442 Ref: Antipsychotic drugs inhibit the function of breast cancer resistance protein. PMID: 18834354 |
Ref: Impact of cellular folate status and epidermal growth factor receptor expression on BCRP/ABCG2-mediated resistance to gefitinib and erlotinib. PMID: 19277036 Ref: Expression and activity of the efflux transporters ABCB1, ABCC2 and ABCG2 in the human colorectal carcinoma cell line LS513. PMID: 19491037 Ref: Involvement of drug transporters in the synergistic action of FOLFOX combination chemotherapy. PMID: 19622348 Ref: [Correlation of chemosensitivity tested using histoculture drug response assay to expression of multidrug resistance genes and proteins in colorectal cancer tissues]. PMID: 19728910 Ref: Polymorphisms in the xenobiotic transporter Multidrug Resistance 1 (MDR1) and interaction with meat intake in relation to risk of colorectal cancer in a Danish prospective case-cohort study. PMID: 19930591 Ref: Drug efflux transporters, MRP1 and BCRP, affect the outcome of hypericin-mediated photodynamic therapy in HT-29 adenocarcinoma cells. PMID: 20024169 |
Ref: CpG island methylation of BNIP3 predicts resistance against S-1/CPT-11 combined therapy in colorectal cancer patients. PMID: 19956881 Ref: Establishment and characterization of 13 human colorectal carcinoma cell lines: mutations of genes and expressions of drug-sensitivity genes and cancer stem cell markers. PMID: 20176655 Ref: Chrysin blocks topotecan-induced apoptosis in Caco-2 cells in spite of inhibition of ABC-transporters. PMID: 20457140 Ref: Aryl hydrocarbon receptor is a transcriptional activator of the human breast cancer resistance protein (BCRP/ABCG2). PMID: 20460431 Ref: Inhibition of Wnt signaling pathway decreases chemotherapy-resistant side-population colon cancer cells. PMID: 20651349 Ref: Expression of ABCG2 and its significance in colorectal cancer. PMID: 21133588 |
Ref: Difluorinated-curcumin (CDF): a novel curcumin analog is a potent inhibitor of colon cancer stem-like cells. PMID: 21161336 Ref: Downregulation of breast cancer resistance protein in colon adenomas reduces cellular xenobiotic resistance and leads to accumulation of a food-derived carcinogen. PMID: 21544799 Ref: Induction of apoptosis in colon cancer cells by a novel topoisomerase I inhibitor TopIn. PMID: 21549095 Ref: Novel acrylonitrile derivatives, YHO-13177 and YHO-13351, reverse BCRP/ABCG2-mediated drug resistance in vitro and in vivo. PMID: 21566063 Ref: Schlafen-3 decreases cancer stem cell marker expression and autocrine/juxtacrine signaling in FOLFOX-resistant colon cancer cells. PMID: 21596996 Ref: The short-chain fatty acid butyrate is a substrate of breast cancer resistance protein. PMID: 21775706 Ref: MC70 potentiates doxorubicin efficacy in colon and breast cancer in vitro treatment. PMID: 21925160 Ref: A combined experimental and mathematical approach for molecular-based optimization of irinotecan circadian delivery. PMID: 21931543 Ref: Coffee induces breast cancer resistance protein expression in Caco-2 cells. PMID: 21963506 Ref: Overexpression of CYP3A4 in a COLO 205 Colon Cancer Stem Cell Model in vitro. PMID: 24212669 |
Ref: ABCG2-overexpressing S1-M1-80 cell xenografts in nude mice keep original biochemistry and cell biological properties. PMID: 22360854 Ref: MicroRNA expression profiling identifies miR-328 regulates cancer stem cell-like SP cells in colorectal cancer. PMID: 22453125 Ref: [Therapeutic effect of axitinib and 5-FU in nude mice bearing human colon cancer xenograft]. PMID: 22699078 Ref: Increased JNK1 signaling pathway is responsible for ABCG2-mediated multidrug resistance in human colon cancer. PMID: 22870247 Ref: The role of microRNA in metastatic colorectal cancer and its significance in cancer prognosis and treatment. PMID: 23173124 |
Ref: [Effect of 5-fluorouracil on the expression of ATP-binding cassette superfamily G member 2 in human colon cancer cell SW480]. PMID: 23355249 Ref: Sildenafil is not a useful modulator of ABCB1 and ABCG2 mediated drug resistance in vivo. PMID: 23422148 Ref: Expression of ABCG2 associated with tumor response in metastatic colorectal cancer patients receiving first-line FOLFOX therapy--preliminary evidence. PMID: 23558935 Ref: MiR-142-3p functions as a tumor suppressor by targeting CD133, ABCG2, and Lgr5 in colon cancer cells. PMID: 23619912 Ref: [Correlation of MDR1 and ABCG2 genetic polymorphisms with the efficacy and adverse events of irinotecan chemotherapy in patients with colorectal cancer]. PMID: 23801203 Ref: Membranous ABCG2 expression in colorectal cancer independently correlates with shortened patient survival. PMID: 23838136 Ref: Sorafenib overcomes irinotecan resistance in colorectal cancer by inhibiting the ABCG2 drug-efflux pump. PMID: 23960095 Ref: Cancer stem cell gene profile as predictor of relapse in high risk stage II and stage III, radically resected colon cancer patients. PMID: 24023782 Ref: Bitter melon extracts enhance the activity of chemotherapeutic agents through the modulation of multiple drug resistance. PMID: 24129966 Ref: In vitro characterization of stem cell-like properties of drug-resistant colon cancer subline. PMID: 24330852 |
Ref: Pien Tze Huang suppresses the stem-like side population in colorectal cancer cells. PMID: 24173665 Ref: Pharmacogenetic predictors of severe peripheral neuropathy in colon cancer patients treated with oxaliplatin-based adjuvant chemotherapy: a GEMCAD group study. PMID: 24351404 Ref: Role of SLC6A6 in promoting the survival and multidrug resistance of colorectal cancer. PMID: 24781822 Ref: Characterization of side population cells isolated from the colon cancer cell line SW480. PMID: 24926880 Ref: Resistance mechanisms of cancer cells to the novel vacuolar H(+)-ATPase inhibitor archazolid B. PMID: 25065443 Ref: Development and validation of an ultra-high performance LC-MS/MS assay for intracellular SN-38 in human solid tumour cell lines: comparison with a validated HPLC-fluorescence method. PMID: 25195021 Ref: CES2, ABCG2, TS and Topo-I primary and synchronous metastasis expression and clinical outcome in metastatic colorectal cancer patients treated with first-line FOLFIRI regimen. PMID: 25198900 Ref: The sensitivity of cancer cells to pheophorbide a-based photodynamic therapy is enhanced by Nrf2 silencing. PMID: 25226504 Ref: ABCG2-meditated multidrug resistance and tumor-initiating capacity of side population cells from colon cancer. PMID: 25427584 Ref: Pien Tze Huang Overcomes Multidrug Resistance and Epithelial-Mesenchymal Transition in Human Colorectal Carcinoma Cells via Suppression of TGF-beta Pathway. PMID: 25505925 |
Ref: Investigation of the functional single-nucleotide polymorphisms in the BCRP transporter and susceptibility to colorectal cancer. PMID: 25469257 Ref: Interactions between meat intake and genetic variation in relation to colorectal cancer. PMID: 25491747 Ref: The c-MET/PI3K signaling is associated with cancer resistance to doxorubicin and photodynamic therapy by elevating BCRP/ABCG2 expression. PMID: 25534417 Ref: IND-2, a pyrimido[1'',2'':1,5]pyrazolo[3,4-b]quinoline derivative, circumvents multi-drug resistance and causes apoptosis in colon cancer cells. PMID: 25537531 Ref: Brain and Testis Accumulation of Regorafenib is Restricted by Breast Cancer Resistance Protein (BCRP/ABCG2) and P-glycoprotein (P-GP/ABCB1). PMID: 25563977 Ref: Germline TYMS genotype is highly predictive in patients with metastatic gastrointestinal malignancies receiving capecitabine-based chemotherapy. PMID: 25677447 Ref: High ABCC2 and low ABCG2 gene expression are early events in the colorectal adenoma-carcinoma sequence. PMID: 25793771 Ref: FL118, a novel camptothecin derivative, is insensitive to ABCG2 expression and shows improved efficacy in comparison with irinotecan in colon and lung cancer models with ABCG2-induced resistance. PMID: 25928015 Ref: Chemoresistance of CD133(+) colon cancer may be related with increased survivin expression. PMID: 26002465 Ref: Identification of a distinct population of CD133(+)CXCR4(+) cancer stem cells in ovarian cancer. PMID: 26020117 Ref: Polymorphisms in ATP-binding cassette transporter genes and interaction with diet and life style factors in relation to colorectal cancer in a Danish prospective case-cohort study. PMID: 26109419 Ref: Prognostic impact of membranous ATP-binding cassette Sub-family G member 2 expression in patients with colorectal carcinoma after surgical resection. PMID: 26176272 Ref: Different Effects of BORIS/CTCFL on Stemness Gene Expression, Sphere Formation and Cell Survival in Epithelial Cancer Stem Cells. PMID: 26185996 Ref: Vatalanib sensitizes ABCB1 and ABCG2-overexpressing multidrug resistant colon cancer cells to chemotherapy under hypoxia. PMID: 26206183 Ref: Inhibition of protein glycosylation reverses the MDR phenotype of cancer cell lines. PMID: 26349962 Ref: Exploiting a novel miR-519c-HuR-ABCG2 regulatory pathway to overcome chemoresistance in colorectal cancer. PMID: 26386386 Ref: OCT4B1 promotes cell growth, migration and invasion suppressing sensitivity to omicronxaliplatin in colon cancer. PMID: 26398480 Ref: ABC-Transporter Expression Does Not Correlate with Response to Irinotecan in Patients with Metastatic Colorectal Cancer. PMID: 26516354 Ref: Novel understanding of ABC transporters ABCB1/MDR/P-glycoprotein, ABCC2/MRP2, and ABCG2/BCRP in colorectal pathophysiology. PMID: 26557010 Ref: Hedyotis diffusa Willd overcomes 5-fluorouracil resistance in human colorectal cancer HCT-8/5-FU cells by downregulating the expression of P-glycoprotein and ATP-binding casette subfamily G member 2. PMID: 26640560 |
Ref: DNA damage-induced ephrin-B2 reverse signaling promotes chemoresistance and drives EMT in colorectal carcinoma harboring mutant p53. PMID: 26494468 Ref: Correlation between the promoter methylation status of ATP-binding cassette sub-family G member 2 and drug sensitivity in colorectal cancer cell lines. PMID: 26497773 Ref: Evodiamine Suppresses ABCG2 Mediated Drug Resistance by Inhibiting p50/p65 NF-kappaB Pathway in Colorectal Cancer. PMID: 26590365 Ref: Histone deacetylase 2 regulates doxorubicin (Dox) sensitivity of colorectal cancer cells by targeting ABCB1 transcription. PMID: 26846508 Ref: Lack of Interactions Between an Antisense Oligonucleotide with 2'-O-(2-Methoxyethyl) Modifications and Major Drug Transporters. PMID: 26959999 Ref: Pyrimido[1'',2'':1,5]pyrazolo[3,4-b]quinolines: Novel compounds that reverse ABCG2-mediated resistance in cancer cells. PMID: 27012188 Ref: Data showing the circumvention of oxaliplatin resistance by vatalanib in colon cancer. PMID: 27014726 Ref: SIRT1 prevents hyperuricemia via the PGC-1alpha/PPARgamma-ABCG2 pathway. PMID: 27022940 Ref: [c-Myc regulation of ATP-binding cassette transporter reverses chemoresistance in CD133(+) colon cancer stem cells]. PMID: 27108904 Ref: 5-Aminolevulinic Acid Fluorescence in Detection of Peritoneal Metastases. PMID: 27221929 Ref: Antibody validation and scoring guidelines for ABCG2 immunohistochemical staining in formalin-fixed paraffin-embedded colon cancer tissue. PMID: 27257141 Ref: Drug membrane transporters and CYP3A4 are affected by hypericin, hyperforin or aristoforin in colon adenocarcinoma cells. PMID: 27261575 Ref: ABCG2 is required for self-renewal and chemoresistance of CD133-positive human colorectal cancer cells. PMID: 27449042 Ref: ABCG2 expression in colorectal adenocarcinomas may predict resistance to irinotecan. PMID: 27698852 Ref: Wnt-beta-catenin signaling regulates ABCC3 (MRP3) transporter expression in colorectal cancer. PMID: 27709738 Ref: Acquisition of anticancer drug resistance is partially associated with cancer stemness in human colon cancer cells. PMID: 27748801 Ref: Bile acid: a potential inducer of colon cancer stem cells. PMID: 27908290 |
Ref: A novel miR-203-DNMT3b-ABCG2 regulatory pathway predisposing colorectal cancer development. PMID: 27253631 Ref: Expression of the cancer stem cell markers ABCG2 and OCT-4 in right-sided colon cancer predicts recurrence and poor outcomes. PMID: 28212529 Ref: What roles do colon stem cells and gap junctions play in the left and right location of origin of colorectal cancers? PMID: 28220297 Ref: Risk analysis of colorectal cancer incidence by gene expression analysis. PMID: 28229027 Ref: Tumour suppressor EP300, a modulator of paclitaxel resistance and stemness, is downregulated in metaplastic breast cancer. PMID: 28341962 Ref: Targeting BCRP/ABCG2 by RNA interference enhances the chemotherapy sensitivity of human colon cancer side population cells. PMID: 28397046 Ref: Aldose reductase inhibitor increases doxorubicin-sensitivity of colon cancer cells and decreases cardiotoxicity. PMID: 28600556 Ref: Upregulation of miR-199a/b contributes to cisplatin resistance via Wnt/beta-catenin-ABCG2 signaling pathway in ALDHA1(+) colorectal cancer stem cells. PMID: 28639895 Ref: Scutellaria barbata D. Don inhibits 5-fluorouracil resistance in colorectal cancer by regulating PI3K/AKT pathway. PMID: 28849113 Ref: Implications of ABCG2 Expression on Irinotecan Treatment of Colorectal Cancer Patients: A Review. PMID: 28880238 Ref: SN38-PEG-PLGA-verapamil nanoparticles inhibit proliferation and downregulate drug transporter ABCG2 gene expression in colorectal cancer cells. PMID: 28948511 Ref: LncRNA CCAT1/miR-130a-3p axis increases cisplatin resistance in non-small-cell lung cancer cell line by targeting SOX4. PMID: 29020498 Ref: Dishevelled1-3 contribute to multidrug resistance in colorectal cancer via activating Wnt/beta-catenin signaling. PMID: 29383202 |
Ref: Multidrug resistant lncRNA profile in chemotherapeutic sensitive and resistant ovarian cancer cells. PMID: 29219179 Ref: Oxaliplatin resistance in colorectal cancer cells is mediated via activation of ABCG2 to alleviate ER stress induced apoptosis. PMID: 29247488 Ref: ABC transporters: Regulation and association with multidrug resistance in hepatocellular carcinoma and colorectal carcinoma. PMID: 29303075 Ref: Lupeol alters ER stress-signaling pathway by downregulating ABCG2 expression to induce Oxaliplatin-resistant LoVo colorectal cancer cell apoptosis. PMID: 29436100 Ref: Rare Variants in the ABCG2 Promoter Modulate In Vivo Activity. PMID: 29467213 Ref: Effects of increased accumulation of doxorubicin due to emodin on efflux transporter and LRP1 expression in lung adenocarcinoma and colorectal carcinoma cells. PMID: 29644529 Ref: Assessing stemness and proliferation properties of the newly established colon cancer 'stem' cell line, CSC480 and novel approaches to identify dormant cancer cells. PMID: 29693155 Ref: Reversal Effects of Bound Polyphenol from Foxtail Millet Bran on Multidrug Resistance in Human HCT-8/Fu Colorectal Cancer Cell. PMID: 29730933 Ref: Upregulation of Breast Cancer Resistance Protein Expression was Decreased in Plasma Membrane of Colon Cancer with Metastasis of Lymphatic Node. PMID: 29739115 Ref: Salvianolic acid B reverses multidrug resistance in nude mice bearing human colon cancer stem cells. PMID: 29845279 Ref: Overcoming stemness and chemoresistance in colorectal cancer through miR-195-5p-modulated inhibition of notch signaling. PMID: 29852230 Ref: Inhibiting ABCG2 could potentially enhance the efficacy of hypericin-mediated photodynamic therapy in spheroidal cell models of colorectal cancer. PMID: 29969677 Ref: Protective role of ABCG2 against oxidative stress in colorectal cancer and its potential underlying mechanism. PMID: 30066914 Ref: Cariprazine, A Dopamine D(2)/D(3) Receptor Partial Agonist, Modulates ABCG2-Mediated Multidrug Resistance in Cancer. PMID: 30181510 Ref: Clinical utility of ABCB1 genotyping for preventing toxicity in treatment with irinotecan. PMID: 30213564 |