Primary Site >> Colorectal Cancer
Gene >> ABCC2
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Ref: Human canalicular multispecific organic anion transporter (cMOAT) is expressed in human lung, gastric, and colorectal cancer cells. PMID: 9398612 |
Ref: Frequent coexpression of MRP/GS-X pump and gamma-glutamylcysteine synthetase mRNA in drug-resistant cells, untreated tumor cells, and normal mouse tissues. PMID: 9515571 |
Ref: [Mechanisms for resistance to anticancer agents and the reversal of the resistance]. PMID: 10695015 |
Ref: Increased expression of an ATP-binding cassette superfamily transporter, multidrug resistance protein 2, in human colorectal carcinomas. PMID: 10873092 Ref: Molecular genetics of cancer susceptibility. PMID: 10971208 |
Ref: Identification of an organic anion transport system in the human colon carcinoma cell line HT29 clone 19A. PMID: 11212217 Ref: Differential sensitivities of the MRP gene family and gamma-glutamylcysteine synthetase to prooxidants in human colorectal carcinoma cell lines with different p53 status. PMID: 11239498 Ref: Characterizing the expression of CYP3A4 and efflux transporters (P-gp, MRP1, and MRP2) in CYP3A4-transfected Caco-2 cells after induction with sodium butyrate and the phorbol ester 12-O-tetradecanoylphorbol-13-acetate. PMID: 11587480 |
Ref: Reversal of drug resistance of hepatocellular carcinoma cells by adenoviral delivery of anti-MDR1 ribozymes. PMID: 12297834 |
Ref: Usefulness of liposomes loaded with cytostatic bile acid derivatives to circumvent chemotherapy resistance of enterohepatic tumors. PMID: 12606785 Ref: Gene expression profiles of ABC transporters and cytochrome P450 3A in Caco-2 and human colorectal cancer cell lines. PMID: 12636175 |
Ref: Glucuronidation as a mechanism of intrinsic drug resistance in colon cancer cells: contribution of drug transport proteins. PMID: 14667926 Ref: Effects of grapefruit juice and orange juice components on P-glycoprotein- and MRP2-mediated drug efflux. PMID: 15504753 |
Ref: Role of pharmacogenetics in irinotecan therapy. PMID: 16343744 Ref: Disposition of 9-nitrocamptothecin and its 9-aminocamptothecin metabolite in relation to ABC transporter genotypes. PMID: 16505951 Ref: Expression of transporters potentially involved in the targeting of cytostatic bile acid derivatives to colon cancer and polyps. PMID: 16844096 Ref: Clinical pharmacokinetics of irinotecan-based chemotherapy in colorectal cancer patients. PMID: 18666754 |
Ref: Paclitaxel-2'-Ethylcarbonate prodrug can circumvent P-glycoprotein-mediated cellular efflux to increase drug cytotoxicity. PMID: 17245652 |
Ref: [Absorption and transport of 6 coumarins isolated from the roots of Angelica pubescens f. biserrata in human Caco-2 cell monolayer model]. PMID: 18405608 Ref: Celecoxib upregulates multidrug resistance proteins in colon cancer: lack of synergy with standard chemotherapy. PMID: 18690847 |
Ref: Expression and activity of the efflux transporters ABCB1, ABCC2 and ABCG2 in the human colorectal carcinoma cell line LS513. PMID: 19491037 Ref: Involvement of drug transporters in the synergistic action of FOLFOX combination chemotherapy. PMID: 19622348 Ref: Radiation- and chemoinduced multidrug resistance in colon carcinoma cells. PMID: 20013091 |
Ref: Establishment and biological characteristics of oxaliplatin-resistant human colon cancer cell lines. PMID: 20591218 |
Ref: Tumor response is predicted by patient genetic profile in rectal cancer patients treated with neo-adjuvant chemo-radiotherapy. PMID: 20368715 Ref: Proteasome inhibitors MG-132 and bortezomib induce AKR1C1, AKR1C3, AKR1B1, and AKR1B10 in human colon cancer cell lines SW-480 and HT-29. PMID: 21215737 Ref: Modulation of doxorubicin resistance by the glucose-6-phosphate dehydrogenase activity. PMID: 21679161 Ref: Irinotecan induces steroid and xenobiotic receptor (SXR) signaling to detoxification pathway in colon cancer cells. PMID: 21733184 Ref: A combined experimental and mathematical approach for molecular-based optimization of irinotecan circadian delivery. PMID: 21931543 |
Ref: Association of ABCC2 genotype with efficacy of first-line FOLFIRI in Japanese patients with advanced colorectal cancer. PMID: 22201120 Ref: Antibody-mediated inhibition of fibroblast growth factor 19 results in increased bile acids synthesis and ileal malabsorption of bile acids in cynomolgus monkeys. PMID: 22268002 Ref: The role of ABC transporters in progression and clinical outcome of colorectal cancer. PMID: 22294766 Ref: ABCC2 transporter gene polymorphisms, diet and risk of colorectal cancer: a Danish prospective cohort study. PMID: 22428913 Ref: Can immunohistochemistry of multidrug-resistant proteins replace the histoculture drug response assay in colorectal adenocarcinomas? PMID: 22580657 Ref: Cisplatin-induced chemoresistance in colon cancer cells involves FXR-dependent and FXR-independent up-regulation of ABC proteins. PMID: 22800197 Ref: [Effects of medicated serum prepared with Chinese herbal medicine Changweiqing on pharmacokinetics of oxaliplatin in colon cancer cells]. PMID: 22883407 Ref: Lack of association between expression of MRP2 and early relapse of colorectal cancer in patients receiving FOLFOX-4 chemotherapy. PMID: 23162618 Ref: Glycogen Synthase Kinase 3beta Inhibitor (2'Z,3'E)-6-Bromo-indirubin- 3'-Oxime Enhances Drug Resistance to 5-Fluorouracil Chemotherapy in Colon Cancer Cells. PMID: 23359767 |
Ref: A prospective validation pharmacogenomic study in the adjuvant setting of colorectal cancer patients treated with the 5-fluorouracil/leucovorin/oxaliplatin (FOLFOX4) regimen. PMID: 22868256 Ref: Multidrug resistance protein 2 genetic polymorphism and colorectal cancer recurrence in patients receiving adjuvant FOLFOX-4 chemotherapy. PMID: 23232902 Ref: Pharmacogenetic analysis of adjuvant FOLFOX for Korean patients with colon cancer. PMID: 23314736 Ref: Dubin-Johnson syndrome coinciding with colon cancer and atherosclerosis. PMID: 23429660 Ref: Therapeutic targeting of CPT-11 induced diarrhea: a case for prophylaxis. PMID: 23597015 Ref: The Myb-p300-CREB axis modulates intestine homeostasis, radiosensitivity and tumorigenesis. PMID: 23618903 Ref: A randomised phase III trial of the pharmacokinetic biomodulation of irinotecan using oral ciclosporin in advanced colorectal cancer: results of the Panitumumab, Irinotecan & Ciclosporin in COLOrectal cancer therapy trial (PICCOLO). PMID: 23953030 Ref: Galectin-3 silencing inhibits epirubicin-induced ATP binding cassette transporters and activates the mitochondrial apoptosis pathway via beta-catenin/GSK-3beta modulation in colorectal carcinoma. PMID: 24303084 |
Ref: Genetic markers for toxicity of adjuvant oxaliplatin and fluoropyrimidines in the phase III TOSCA trial in high-risk colon cancer patients. PMID: 25370899 |
Ref: Interactions between meat intake and genetic variation in relation to colorectal cancer. PMID: 25491747 Ref: Germline TYMS genotype is highly predictive in patients with metastatic gastrointestinal malignancies receiving capecitabine-based chemotherapy. PMID: 25677447 Ref: Regorafenib is transported by the organic anion transporter 1B1 and the multidrug resistance protein 2. PMID: 25739790 Ref: High ABCC2 and low ABCG2 gene expression are early events in the colorectal adenoma-carcinoma sequence. PMID: 25793771 Ref: Polymorphisms in ATP-binding cassette transporter genes and interaction with diet and life style factors in relation to colorectal cancer in a Danish prospective case-cohort study. PMID: 26109419 Ref: Multidrug Resistance-Associated Protein 2 Expression Is Upregulated by Adenosine 5'-Triphosphate in Colorectal Cancer Cells and Enhances Their Survival to Chemotherapeutic Drugs. PMID: 26295158 Ref: Novel understanding of ABC transporters ABCB1/MDR/P-glycoprotein, ABCC2/MRP2, and ABCG2/BCRP in colorectal pathophysiology. PMID: 26557010 |
Ref: Histone deacetylase 2 regulates doxorubicin (Dox) sensitivity of colorectal cancer cells by targeting ABCB1 transcription. PMID: 26846508 Ref: Data showing the circumvention of oxaliplatin resistance by vatalanib in colon cancer. PMID: 27014726 Ref: Drug membrane transporters and CYP3A4 are affected by hypericin, hyperforin or aristoforin in colon adenocarcinoma cells. PMID: 27261575 Ref: DNA copy number alterations, gene expression changes and disease-free survival in patients with colorectal cancer: a 10 year follow-up. PMID: 27709558 Ref: Wnt-beta-catenin signaling regulates ABCC3 (MRP3) transporter expression in colorectal cancer. PMID: 27709738 Ref: Acquisition of anticancer drug resistance is partially associated with cancer stemness in human colon cancer cells. PMID: 27748801 |
Ref: Dihydromyricetin reverses MRP2-mediated MDR and enhances anticancer activity induced by oxaliplatin in colorectal cancer cells. PMID: 27997436 Ref: 2-Deoxy-D-glucose suppresses the migration and reverses the drug resistance of colon cancer cells through ADAM expression regulation. PMID: 28059830 Ref: Usefulness of the MRP2 promoter to overcome the chemoresistance of gastrointestinal and liver tumors by enhancing the expression of the drug transporter OATP1B1. PMID: 28423714 Ref: HES1 Promotes Colorectal Cancer Cell Resistance To 5-Fu by Inducing Of EMT and ABC Transporter Proteins. PMID: 28928869 Ref: Modulation of the mRNA-binding protein HuR as a novel reversal mechanism of epirubicin-triggered multidrug resistance in colorectal cancer cells. PMID: 28968471 Ref: Phenolic compounds, antioxidant activity, antiproliferative activity and bioaccessibility of Sea buckthorn (Hippophae rhamnoides L.) berries as affected by in vitro digestion. PMID: 29046908 Ref: Common variants in glucuronidation enzymes and membrane transporters as potential risk factors for colorectal cancer: a case control study. PMID: 29282011 Ref: Dishevelled1-3 contribute to multidrug resistance in colorectal cancer via activating Wnt/beta-catenin signaling. PMID: 29383202 |
Ref: N-3 Polyunsaturated Fatty Acids Stimulate Bile Acid Detoxification in Human Cell Models. PMID: 29850457 |