Primary Site >> Liver Cancer
Gene >> ABCB4
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Ref: Overexpression of the multidrug resistance gene mdr3 in spontaneous and chemically induced mouse hepatocellular carcinomas. PMID: 2122232 |
Ref: Activation of multidrug resistance (P-glycoprotein) mdr3/mdr1a gene during the development of hepatocellular carcinoma in hepatitis B virus transgenic mice. PMID: 1356418 |
Ref: Constitutive expression of functional P-glycoprotein in rat hepatoma cells. PMID: 7905826 |
Ref: Regulation and function of the multidrug resistance genes in liver. PMID: 9224499 |
Ref: Correction of liver disease by hepatocyte transplantation in a mouse model of progressive familial intrahepatic cholestasis. PMID: 11113093 |
Ref: Gene expression of ABC proteins in hepatocellular carcinoma, perineoplastic tissue, and liver diseases. PMID: 12428063 |
Ref: NF-kappaB functions as a tumour promoter in inflammation-associated cancer. PMID: 15329734 |
Ref: Hepatobiliary transporter expression in human hepatocellular carcinoma. PMID: 15780063 Ref: Increase of doxorubicin sensitivity by doxorubicin-loading into nanoparticles for hepatocellular carcinoma cells in vitro and in vivo. PMID: 15826724 |
Ref: Multiple adaptive mechanisms to chronic liver disease revealed at early stages of liver carcinogenesis in the Mdr2-knockout mice. PMID: 16618719 |
Ref: Molecular mechanisms of the chemopreventive effect on hepatocellular carcinoma development in Mdr2 knockout mice. PMID: 17431106 Ref: Molecular mechanisms of liver carcinogenesis in the mdr2-knockout mice. PMID: 18025261 |
Ref: Progressive familial intrahepatic cholestasis. PMID: 19133130 Ref: A missense mutation in ABCB4 gene involved in progressive familial intrahepatic cholestasis type 3 leads to a folding defect that can be rescued by low temperature. PMID: 19185004 Ref: HCV tumor promoting effect is dependent on host genetic background. PMID: 19340302 Ref: S100A8 and S100A9 are novel nuclear factor kappa B target genes during malignant progression of murine and human liver carcinogenesis. PMID: 19670424 Ref: Hepatic tumor-stroma crosstalk guides epithelial to mesenchymal transition at the tumor edge. PMID: 19718050 |
Ref: Accelerated carcinogenesis following liver regeneration is associated with chronic inflammation-induced double-strand DNA breaks. PMID: 20133864 Ref: Innovative immunohistochemistry identifies MMP-9 expressing macrophages at the invasive front of murine HCC. PMID: 21160992 Ref: Oral methylthioadenosine administration attenuates fibrosis and chronic liver disease progression in Mdr2-/- mice. PMID: 21209952 |
Ref: ABC transporters, bile acids, and inflammatory stress in liver cancer. PMID: 21118090 Ref: Vascular profile characterization of liver tumors by magnetic resonance imaging using hemodynamic response imaging in mice. PMID: 21390187 Ref: Hedgehog signaling antagonist promotes regression of both liver fibrosis and hepatocellular carcinoma in a murine model of primary liver cancer. PMID: 21912653 Ref: Hepatocyte IKK2 protects Mdr2-/- mice from chronic liver failure. PMID: 22022477 |
Ref: Induction of heme oxygenase 1 prevents progression of liver fibrosis in Mdr2 knockout mice. PMID: 21953613 Ref: Aspects of liver pathology in adult patients with MDR3/ABCB4 gene mutations. PMID: 22331132 Ref: Expression of multi-drug resistance-related genes MDR3 and MRP as prognostic factors in clinical liver cancer patients. PMID: 22366465 |
Ref: Lysophosphatidic acid aberrancies and hepatocellular carcinoma: studies in the MDR2 gene knockout mouse. PMID: 23362952 Ref: Receptor for advanced glycation endproducts (RAGE) is a key regulator of oval cell activation and inflammation-associated liver carcinogenesis in mice. PMID: 23504974 Ref: Endogenous retrotransposition activates oncogenic pathways in hepatocellular carcinoma. PMID: 23540693 Ref: Activation of the nuclear receptor FXR enhances hepatocyte chemoprotection and liver tumor chemoresistance against genotoxic compounds. PMID: 23680185 |
Ref: p21 promotes sustained liver regeneration and hepatocarcinogenesis in chronic cholestatic liver injury. PMID: 24092862 Ref: Specific genomic and transcriptomic aberrations in tumors induced by partial hepatectomy of a chronically inflamed murine liver. PMID: 25401338 Ref: Progressive familial intrahepatic cholestasis. PMID: 25755532 |
Ref: Expression of indocyanine green-related transporters in hepatocellular carcinoma. PMID: 25173835 Ref: Growth hormone resistance exacerbates cholestasis-induced murine liver fibrosis. PMID: 25179284 Ref: Chronic liver inflammation and hepatocellular carcinogenesis are independent of S100A9. PMID: 25331529 Ref: A new Mdr2(-/-) mouse model of sclerosing cholangitis with rapid fibrosis progression, early-onset portal hypertension, and liver cancer. PMID: 25478810 Ref: Exploring the Molecular Mechanism and Biomakers of Liver Cancer Based on Gene Expression Microarray. PMID: 25907256 Ref: Chronic liver inflammation modifies DNA methylation at the precancerous stage of murine hepatocarcinogenesis. PMID: 25918251 Ref: Evaluation of 11C-acetate and 18F-FDG PET/CT in mouse multidrug resistance gene-2 deficient mouse model of hepatocellular carcinoma. PMID: 25981587 Ref: Science to Practice: The Changing Face of Local Tumor Therapies-Do We Have to Think Systemically When Treating Cancer Locally? PMID: 26203703 Ref: Oncogenesis: An "Off-Target" Effect of Radiofrequency Ablation. PMID: 26203709 |
Ref: Deficiency of multidrug resistance 2 contributes to cell transformation through oxidative stress. PMID: 26542370 Ref: Epithelial Transforming Growth Factor-beta Signaling Does Not Contribute to Liver Fibrosis but Protects Mice From Cholangiocarcinoma. PMID: 26627606 Ref: Sorafenib treatment during partial hepatectomy reduces tumorgenesis in an inflammation-associated liver cancer model. PMID: 26695439 Ref: TGF-beta1 and TGF-beta2 abundance in liver diseases of mice and men. PMID: 26799667 Ref: Dietary Protective Effects Against Hepatocellular Carcinoma Development in Mdr2-/- Knockout Mice. PMID: 27381607 Ref: TLR4 Deficiency Protects against Hepatic Fibrosis and Diethylnitrosamine-Induced Pre-Carcinogenic Liver Injury in Fibrotic Liver. PMID: 27391331 Ref: Irreversible Electroporation versus Radiofrequency Ablation: A Comparison of Local and Systemic Effects in a Small-Animal Model. PMID: 27429143 Ref: Deletion of interleukin-6 in monocytes/macrophages suppresses the initiation of hepatocellular carcinoma in mice. PMID: 27589954 |
Ref: Functional role of CCL5/RANTES for HCC progression during chronic liver disease. PMID: 28011329 Ref: Interleukin 6-dependent genomic instability heralds accelerated carcinogenesis following liver regeneration on a background of chronic hepatitis. PMID: 28027584 Ref: Hepatocarcinogenesis in multidrug-resistant P-glycoprotein 3 deficiency. PMID: 28127842 Ref: ABCB4 missense mutations D243A, K435T, G535D, I490T, R545C, and S978P significantly impair the lipid floppase and likely predispose to secondary pathologies in the human population. PMID: 28220208 Ref: Hepatocyte specific TIMP3 expression prevents diet dependent fatty liver disease and hepatocellular carcinoma. PMID: 28751722 Ref: Tumor-suppressive effect of S-adenosylmethionine supplementation in a murine model of inflammation-mediated hepatocarcinogenesis is dependent on treatment longevity. PMID: 29285212 |
Ref: B lymphocytes limit senescence-driven fibrosis resolution and favor hepatocarcinogenesis in mouse liver injury. PMID: 29105104 Ref: L1 retrotransposition is a common feature of mammalian hepatocarcinogenesis. PMID: 29643204 Ref: MiR-873-5p acts as an epigenetic regulator in early stages of liver fibrosis and cirrhosis. PMID: 30237481 |