literature

SARS_CoV_2 mutation literature information.

Geographic and Genomic Distribution of SARS-CoV-2 Mutations.

PMID: 32793182 2020 Frontiers in microbiology

Table: Y541C

Characterizing SARS-CoV-2 mutations in the United States.

PMID: 32818213 2020 Research square

Introduction: Among them, mutations 17858A>G-(Y541C), 17747C>T-(P504L), and 27964C>T-(S24L) were originated and prevalent mainly in the US, attributing to the unique characteristics of COVID-19 in the US.

Introduction: Based on co-mutation and time evolution analysis, we hypothesize that three concurrent mutations 17747C>T-(P504L), 17858A>G-(Y541C), and 28144T>C tend to fade out, while the other five concurrent mutations can enhance the infectivity of SARS-CoV-2.

Introduction: Based on genotyping results, top eight missense mutations (i.e.,

BioAider: An efficient tool for viral genome analysis and its application in tracing SARS-CoV-2 transmission.

PMID: 32904401 2020 Sustainable cities and society

Abstract: NSP13-Y541C was crucial substitution which might affect the unwinding activity of the viral helicase.

Result: Since the 541th aa is one of the known key sites of NSP13 for binding to nucleic acids in SARS-CoV, the non-synonymous substitution hotspot of ORF1ab-Y5865C (NSP13-Y541C) in NSP13 probably affects the function of NSP13.

Figure: SARS-CoV (AY291315.1), SARS-CoV-2_referential (EPI_ISL_402119), SARS-CoV-2_NSP13-P504L_Y541C (EPI_ISL_413456), Bat-CoV RaTG13 (MN996532.1), Bat-CoV_RmYN02 (EPI_ISL_412977), Pangolin-CoV (EPI_ISL_

Evaluation of the potency of FDA-approved drugs on wild type and mutant SARS-CoV-2 helicase (Nsp13).

PMID: 32980406 2020 International journal of biological macromolecules

Result: Both P504L and Y541C mutations were in the 2A domain and caused a more hydrophobic 2A domain.

Result: Especially, Y541C mutation was very close to the ATP hydrolysis site and previous in silico study on SARS-CoV-2 helicase showed that the compounds interacted with nearby residues including D534, S535 and S539.

Result: In this way, the difference in sites P504L and Y541C, where there are amino acid changes, can be analyzed with reference to the wild type.

Result: It was found that the sapropterin interacted within the ATP-binding site with Gln404 and the residues adjacent to the mutation site of Y541C (Gln537, Gly538, Glu540) (Supplement File 1.

Result: Two substitutions causing missense mutations (

PMID: 33015402 2020 Heliyon

Table: Y541C

Potentially adaptive SARS-CoV-2 mutations discovered with novel spatiotemporal and explainable AI models.

PMID: 33357233 2020 Genome biology

Result: 2) involves two haplotypes found in the state of Washington in the USA that correspond to nearly adjacent mutations in the nsp13 protein (Pro504Leu and Tyr541Cys).

Result: However, we find 11 individuals from nearby British Columbia, Canada, that are infected with a SARS-CoV-2 harboring only the Tyr541Cys variant and not the Pro504Leu.

Result: The double substitution, Pro504Leu and Tyr541Cys, defines a large clade that is mostly present in North America (92% of individuals with the mutations).

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