literature

SARS_CoV_2 mutation literature information.

Effects of SARS-CoV-2 mutations on protein structures and intraviral protein-protein interactions.

PMID: 33090512 2021 Journal of medical virology

Result: In particular, there were also some mutation combinations, such as P504L/Y541C in nsp13 and R203K/G204R in N (Table S1).

Genetic conservation of SARS-CoV-2 RNA replication complex in globally circulating isolates and recently emerged variants from humans and minks suggests minimal pre-existing resistance to remdesivir.

PMID: 33549572 2021 Antiviral research

Result: Nsp13 substitutions P504L and Y541C decreased in frequency over time.

Table: Y541C

Analysis of SARS-CoV-2 mutations in the United States suggests presence of four substrains and novel variants.

PMID: 33589648 2021 Communications biology

Introduction: Additionally, three concurrent missense mutations 17747C>T-(P504L), 17858A>G-(Y541C), and 28144T>C-(L84S) tend to fade out, while the other eight concurrent mutations may enhance the infectivity of SARS-CoV-2.

Result: Among them, 3 mutations are synonymous ones (i.e., 3037C>T-(F106F), 8782C>T-(S76S), and 18060C>T-(L7L)) and 11 mutations are the missense mutations (i.e., 1059C>T-(T85I), 14408C>T-(P323L),

Whole genome analysis of more than 10 000 SARS-CoV-2 virus unveils global genetic diversity and target region of NSP6.

PMID: 33725111 2021 Briefings in bioinformatics

Table: Y541C

Molecular epidemiology analysis of early variants of SARS-CoV-2 reveals the potential impact of mutations P504L and Y541C (NSP13) in the clinical COVID-19 outcomes.

PMID: 33798758 2021 Infection, genetics and evolution

Abstract: Haplotype maps and phylogenetic tree analysis showed that amino acid variations in ORF1ab (p.5828P > L and p.5865Y > C, also NSP13: P504L and NSP13: Y541C) were the important characteristics of such clade.

Introduction: Based on the infection, fatality, and recovery rates, as well as dynamic curves for the emergence of genome variations, in different countries, we identified amino acid variations in ORF1ab at the 5828 and 5865 loci (NSP13: P504L and NSP13: Y541C) and gained insight into COVID-19 outcomes in the United States that contained different proportions of strains

Impact of meteorological parameters and population density on variants of SARS-CoV-2 and outcome of COVID-19 pandemic in Japan.

PMID: 33908339 2021 Epidemiology and infection

Table: Y541C

Global variation in SARS-CoV-2 proteome and its implication in pre-lockdown emergence and dissemination of 5 dominant SARS-CoV-2 clades.

PMID: 34147651 2021 Infection, genetics and evolution

Result: In Nsp13, the exchange between the aliphatic A18 and V18 (PF = 1.1%), P504L (PF = 5.6%) and Y541C (PF = 5.8%) are found with the moderate recurrence.

Correlates of SARS-CoV-2 Variants on Deaths, Case Incidence and Case Fatality Ratio among the Continents for the Period of 1 December 2020 to 15 March 2021.

PMID: 34356077 2021 Genes

Abstract: While the NSP13_Y541C, NSP3_T73I and NSP3_Q180H mutations demonstrated a negative correlation to CFR.

Conclusion: Among the identified mutati

Result: However, NSP3_T73I and NSP3_Q180H, NSP13_Y541C showed a negative correlation to CFR (Figure 3A-C).

Analysis of 329,942 SARS-CoV-2 records retrieved from GISAID database.

PMID: 34735950 2021 Computers in biology and medicine

Discussion: T85I is noted to co-occur with Q57H, and P504L - with Y541C.

Structural Analysis on the Severe Acute Respiratory Syndrome Coronavirus 2 Non-structural Protein 13 Mutants Revealed Altered Bonding Network With TANK Binding Kinase 1 to Evade Host Immune System.

PMID: 34925297 2021 Frontiers in microbiology

Introduction: The mutations P504L and Y541C in NSP13 were important for different disease outcomes.

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