SARS-CoV-2 Variants, RBD Mutations, Binding Affinity, and Antibody Escape.
PMID: 34829998
2021
International journal of molecular sciences
Introduction: Surprisingly, the mutations of L452R, K417N, Y453F, E484K N501Y, and F490S transform the Ho-Hi interactions into Ho-Ho or ADD interactions at these positions, thus increasing the binding affinity with ACE2.
Introduction: There have been a number of missense mutations observed in the receptor-binding domain (RBD) of the SARS-CoV-2 S protein, which have presented in one or more of the VOCs, including the N440K, G446V, L452R, Y453F, E484Q, F490S, N501Y
Spatial epidemiology and genetic diversity of SARS-CoV-2 and related coronaviruses in domestic and wild animals.
Abstract: In dog, cat, gorilla, lion, and tiger, Y505H and Y453F were the common mutations followed by Y145del, Y144del, and V70I in S protein.
Abstract: The mink variant mutation (spike_Y453F) was detected in both humans and domestic cats.
Figure: Star (*) indicates mink variant mutation in spike protein (Spike_Y453F) reported in mink and humans.
Discussion: The common mutations were Y505H and Y453F in different animal species including dog, cat, lion, tiger, and gorilla.
Discussion: The mutation PMID: 34940505
2021
Journal of developmental biology
Introduction: Its appearance is recurrent and often co-occurs with N439K, Y453F, and N501Y mutations, suggesting a selective advantage and possible epistasis between mutations, which should be further examined.
Introduction: Mutation Y453F, along with N439K, G446V, K444E, and S477N, among others, which are located at the interface between the S1 and ACE2, have been shown to partially interfere with antibody binding and neutralization.
Multiple SARS-CoV-2 variants escape neutralization by vaccine-induced humoral immunity.
Introduction: There have also been reports of SARS-CoV-2 transmission between humans and minks in Denmark with a variant called mink cluster 5 or B.1.1.298, which harbors a two-amino acid deletion and four missense mutations including Y453F in RBD.
Result: Separately, the B.1.1.298 variant found in Danish minks contained a Y453F mutation in RBD, and the California variant B.1.429 contained an L452R mutation.
Result: When assessing variants containing one RBD mutation as part of their mutational landscape, the UK variant B.1.1.7 (N501Y), Danish mink variant B.1.1.298 (Y453F), and California variant B.1.429 (L452R) exhibited neutralization that was generally similar t
Will Mutations in the Spike Protein of SARS-CoV-2 Lead to the Failure of COVID-19 Vaccines?
PMID: 33975397
2021
Journal of Korean medical science
Method: Among these mutations, five (L18F, S98F, A262S, A222V, and P272L) occurred in the N-terminal domain (NTD) of the S protein, and five (N439K, Y453F, S477N, E484K, and N501Y) appeared in the S protein RBD.
Method: There were 13 nonsynonymous mutations with a total frequency of > 1,000, and three mutations that are of interest, including D614G, A222V, L18F, S477N
Mutation Signatures and In Silico Docking of Novel SARS-CoV-2 Variants of Concern.
Discussion: Furthermore, some variants such as mink SARS-CoV-2 variant with the Y453F mutation in RBD of S-protein known to escape neutralizing antibodies, however, with restricted geographical spread during outbreak (mainly detected in Denmark and the Netherlands), were also not considered as a variant of concern.
Dieckol and Its Derivatives as Potential Inhibitors of SARS-CoV-2 Spike Protein (UK Strain: VUI 202012/01): A Computational Study.
Introduction: Of note, Tyr453Phe and Asn501Tyr mutations are located in the receptor-binding domain (RBD) of SARS-CoV-2.
Introduction: The new variant is characterized by many mutations such as Delta69-70, Delta144, Tyr453Phe, Asn501Tyr, Ala570Asp, Asp614Gly, Phe681His, Thr716Ile, Ser982Ala, and Asp1118His in the spike protein.
Method: A model of UK SARS-CoV-2 Spike protein RBD was generated by inserting Tyr453Phe and Asn501Tyr
The Genetic Variant of SARS-CoV-2: would It Matter for Controlling the Devastating Pandemic?
PMID: 33907511
2021
International journal of biological sciences
Introduction: In addition, the simultaneous mutations of DeltaH69/DeltaV70 and Y453F were also found in several other variants closely related to cluster 5 with high frequency.
Introduction: In this variant, five mutations appeared on the S protein, including: Y453F, a H69/V70 deletion (DeltaH69/DeltaV70), I692V, S1147L and M1229I.
Introduction: The Y453F mutation locates in the RBD that directly contacts the host ACE2 at amino acid 34.
SARS-CoV-2 mutations acquired in mink reduce antibody-mediated neutralization.
Discussion: Alternatively, Y453F might be the result of viral evasion of the antibody response, and a recent report on emergence of Y453F in a patient with long-term COVID-19 supports this possibility.
Discussion: Further, we did not investigate whether presence of Y453F in the SARS-CoV-2 S protein increases binding to mink ACE2.
Discussion: However, entry into certain cell lines was reduced when Y453F was combined with H69Delta, V70Delta, I692V, and M1229I, as found in the S protein of the SARS-CoV-2 cluster 5 variant.
Discussion: In keeping with this finding, a combination of casirivimab/REGN10933 and imdevimab/REGN10987 efficiently blocked SARS-CoV-2 w
Functional evaluation of the P681H mutation on the proteolytic activation the SARS-CoV-2 variant B.1.1.7 (Alpha) spike.
Discussion: As explained for other variants (including D614G in humans and Y453F in mink ), we consider that the rise of P681H-containing viruses could be due to chance, with founder effects being responsible for rapid progression, or P681H may confer an advantage with regards transmissibility or cell-cell spread in vivo.
SARS_CoV_2 mutation literature information.
PMID: 
2021
International journal of molecular sciences
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