Result: DeltaH69/V70 was first detected in the Y453F background on August 24, 2020 and so far appears to be limited to Danish sequences (Figures 1 and 5B), although an independent acquisition was recently reported along with DeltaH69/V70 in an immune-compromised Russian individual with chronic infection.
Result: The second significant cluster with DeltaH69/V70 and RBD mutants involves Y453F, another spike RBD mutation that increases binding affinity to ACE2, and has been found to be associated with mink-human infection.
Result: We hypothesized that DeltaH69/V70 might have arisen after Y453F and N439K to compensate for potential loss of infectivity, which has been reported previously for these RBD
Epitope Classification and RBD Binding Properties of Neutralizing Antibodies Against SARS-CoV-2 Variants of Concern.
Result: In contrast to the invariant residues, 9 ACE2 binding residues (K417, G446, L455, A475, G476, E484, F486, and N501) have undergone significant sequence variation ( Figure 2 ) with the largest frequencies occurring at four positions: N501Y (0.208%), E484K (0.079%), Y453F (0.062%), and F486L (0.059%).
Result: The N501Y variant, which occurs at the highest frequency, is the only residue located within the RBD knob, while Y453F is located in the RBD base and E484K and F486L are localized in the tip ( Figure 2A ).
Result: Thus, C1 NAb epitopes are predicted to be sensitive to K417N/T,
Recent progress on the mutations of SARS-CoV-2 spike protein and suggestions for prevention and controlling of the pandemic.
PMID: 34146731
2021
Infection, genetics and evolution
Abstract: Among these mutations, the most representative ones are substitution mutations such as D614G, N501Y, Y453F, N439K/R, P681H, K417N/T, and E484K, and deletion mutations of DeltaH69/V70 and Delta242-244, which confer the virus with enhanced infectivity, transmissibility, and resistance to neutralization.
Introduction: Furthermore, more than 1500 mutations in SARS-CoV-2 have been identified in Russia, and 18 mutations of SARS-CoV-2 were found in a Russian woman with low immunity, some of which are the same as the mutated virus appearing in Britain, and two others are consistent with the variant carried by Danish mink (Y453F and Delta69-70 HV).
Introduction: The most representative ones
Bioinformatics Analysis Unveils Certain Mutations Implicated in Spike Structure Damage and Ligand-Binding Site of Severe Acute Respiratory Syndrome Coronavirus 2.
PMID: 34121839
2021
Bioinformatics and biology insights
Result: The most common mutations were found to be D614G (39 mutations), H49Y (3 mutations), Y453 F (8 mutations), G261D (6 mutations), A845S (4 mutations), T676I (2 mutations), S254F (2 mutations), and I197V (2 mutations), respectively, while the others that have only one mutation are shown on Table 2.
Table: Y453F
SARS-CoV2 spike protein gene variants with N501T and G142D mutation-dominated infections in mink in the United States.
PMID: 34109885
2021
Journal of veterinary diagnostic investigation
Abstract: Large numbers of mink have been infected with SARS-CoV2 containing the spike protein Y453F mutation in Europe, causing zoonosis concerns.
Abstract: The Y453F mutation was not identified in the mink-derived sequences in the United States and Canada.
Introduction: Large numbers of mutants with Y453F mutations were found in infected mink in Denmark, which may have spread from human to animal and back to humans.
Introduction: The N501Y mutation that was common to U.K., South African, and Brazilian variants, and the Y453F mutation that widely prevailed in COVID-19-positive mink in Denmark and the Netherlands were absent in all U.S.
The Spike of Concern-The Novel Variants of SARS-CoV-2.
Introduction: The Y453F mutation arose several times independently in different sub-lineages, was found as an escape mutant in in vitro experiments, and increases hAce2 affinity four-fold (Table 2).
Introduction: The so-called cluster 5 strain contains the same two N-terminal deletions (DeltaH69, DeltaV70) as the UK B.1.1.7 Spike as well as the three mutations Y453F, I692V, and M1229I in addition to D614G (Table 1).
Exploring the Role of Glycans in the Interaction of SARS-CoV-2 RBD and Human Receptor ACE2.
Result: In fact, of these seven RBD residues, two are sites where the common mutations Y453F and N501Y occur, and the remaining five are highly conserved among pandemic variants.
Result: Specifically, Y453F is a mutation that originates from minks in Denmark and has been found in over 1400 out of ~314,000 sequences recorded globally (i.e.,global frequency), as of 16 January 2021.
Convalescent-Phase Sera and Vaccine-Elicited Antibodies Largely Maintain Neutralizing Titer against Global SARS-CoV-2 Variant Spikes.
Introduction: In addition, a variant found in domesticated minks in Denmark, designated mink cluster 5 (Delta69-70/Y453F/I692V/M1229I), has the potential for transfer to humans.
Result: Analysis of the single point mutations showed that the decrease in neutralizing titers was caused by E484K, K417N, and Y453F mutations.
Result: Pseudotyped viruses with the mink-associated mutations were fully infectious except for the
Table: Y453F
Discussion: The mutations that affected REGN10933 (E484K, K417N, and Y453F) cluster on the face of the RBD to which the antibody binds.
A core-shell structured COVID-19 mRNA vaccine with favorable biodistribution pattern and promising immunity.
PMID: 34059617
2021
Signal transduction and targeted therapy
Discussion: The variants such as Y453F, N439K, N501Y, and E484K have shown either enhanced cross-species transmissibility or ability to escape neutralization by NAbs.
SARS_CoV_2 mutation literature information.
PMID: 
2021
Immunity
Browser Board
Co-occurred Entities
Filtrator
ViMRT