Zoonotic spill-over of SARS-CoV-2: mink-adapted virus in humans.
PMID: 34920116
2022
Clinical microbiology and infection
Abstract: RESULTS: In an isolate obtained from an asymptomatic patient testing positive for SARS-CoV-2, we found four distinguishing mutations in the S gene that gave rise to the mink-adapted variant (G75V, M177T, Y453F, and C1247F) and others.
Discussion: In an isolate obtained from an asymptomatic farm employee testing positive for SARS-CoV-2, we found four distinguishing mutations in the S gene that gave rise to the mink-adapted variant (G75V, M177T, Y453F, and C1247F) and others.
Discussion: These new changes include the Y453F mutation, which was previously reported to have emerged in minks durin
E484K and N501Y SARS-CoV 2 spike mutants Increase ACE2 recognition but reduce affinity for neutralizing antibody.
PMID: 34915409
2022
International immunopharmacology
Introduction: N439K, L452R, and Y453F showed an increase in ACE2 receptor binding ability.
Introduction: On the other hand, an ELISA-based ACE2/RBD inhibition assay reports Y453F RBD mutant does not decrease established humoral immunity from previously infected individuals or affect the neutralizing antibody response.
Table: Y453F
Longitudinal analysis of SARS-CoV-2 spike and RNA-dependent RNA polymerase protein sequences reveals the emergence and geographic distribution of diverse mutations.
PMID: 34801754
2022
Infection, genetics and evolution
Figure: The mutation Y453F would result in the loss of a hydroxyl group, which may reduce steric clashing with the histidine residue.
Role of the Microbiome in the Pathogenesis of COVID-19.
PMID: 35433495
2022
Frontiers in cellular and infection microbiology
Table: Y453F
Crucial Mutations of Spike Protein on SARS-CoV-2 Evolved to Variant Strains Escaping Neutralization of Convalescent Plasmas and RBD-Specific Monoclonal Antibodies.
Figure: Eight mutations (Y453F, L455F, F456L, A475V, A475S, T500S, N501Y, and Y505H) were in the RBD and hACE2 interaction region (RBD/hACE2); 10 mutations (V367I, V382L, R408G, N438K, L452Q, S477N, T478K, E484Q, S494P, and A520S) were in the RBD region but no
Evolutionary Tracking of SARS-CoV-2 Genetic Variants Highlights an Intricate Balance of Stabilizing and Destabilizing Mutations.
Abstract: The viral strains belonged to lineages B.1.1.218 and B.1.1.305, possessing the mink-specific S-Y453F substitution.
Result: The mink specific S protein amino-acid substitution ( Table: Y453F
Discussion: Although more data are needed to elucidate the evolution of SARS-CoV-2 variants in minks, the independent presence of Y453F in Greek mink farms suggests its positive selection for mink-specific mutations.
Discussion: Most single-nucleotide polymorphisms (SNPs) found within the S gene were mostly accumulated in the spike protein RBM region, with the mink-specific amino-acid substitution (S-Y453F) being present in all sequenced genomes.
Understanding the molecular interaction of SARS-CoV-2 spike mutants with ACE2 (angiotensin converting enzyme 2).
PMID: 34495817
2021
Journal of biomolecular structure & dynamics
Introduction: A recurrent emergence and significant onward transmission of a mutation in the spike gene which result in loss of H69/V70 has recently been reported to co-occur with the receptor binding motif (RBM) amino acid substitutions N501Y, N439K and Y453F (Kemp et al.,).
Dynamics prediction of emerging notable spike protein mutations in SARS-CoV-2 implies a need for updated vaccines.
Method: The chosen sequences of single mutations included the following amino acid substitutions: L5F, L18F, D80A, S98F, A222V, A262S, P272L, K417 N, N439K, L452R, Y453F, S477 N, E484K, E484Q, N501T, N501Y, E583D, D614G, Q675H, Q675P, Q677H, PMID: 34531417
2021
Scientific reports
Result: However, RBD mutants S477N
Discussion: The Y453F mutation was originally identified in a variant isolated from farmed minks.
Discussion: The evaluation of several RBD mutations in a competition assay indicated that two mutations, Y453F and N501Y, increased apparent affinity of RBD to ACE2 eight to tenfold compared to wild type RBD.
Discussion: To evaluate the effect of these mutations on antibody binding and RBD:ACE2 PPI inhibition, we generated RBD-Fc variants containing the mutations Y453F, N501Y and E484K.
SARS_CoV_2 mutation literature information.
PMID: 
2022
Clinical microbiology and infection
Browser Board
Co-occurred Entities
Filtrator
ViMRT