Introduction: Additional mutations are found in the BA.1 spike protein, including 10 substitutions (A67V, T95I, Y145D, L212I, S371L, G446S, G496S, T547K, N856K, and L981F), three deletions (H69-/V70-, G142-/V143-/Y144-, and N211-) and a three amino-acid insertion at position 214.
Introduction: Additional mutations found in the Omicron variant (e.g., A67V, T95I, G142-/V143-/Y144-/Y145D, and N211-/L212I) are associated with infectious
Role of the Microbiome in the Pathogenesis of COVID-19.
PMID: 35433495
2022
Frontiers in cellular and infection microbiology
Table: Y145D
Characteristic analysis of Omicron-included SARS-CoV-2 variants of concern.
Result: While the scores of A67V, Y145D, and N440K on NTD and RBD decreased more, the scores of S371L, S373P, S375F, G446S, and S447N on RBD only slightly decreased (Figure 2E).
A Combination of Receptor-Binding Domain and N-Terminal Domain Neutralizing Antibodies Limits the Generation of SARS-CoV-2 Spike Neutralization-Escape Mutants.
Abstract: As seen with some of the natural VOC, the neutralization potencies of COVID-19 convalescent-phase sera were reduced by 4- to 16-fold against rVSV-SARS2 bearing Y145D, K150E, or W152R spike mutations.
Result: For the NTD MAb (ADI-56479), rVSV-SARS2 neutralization-escape mutations mapped to residues 145 (Y145D), 150 (K150E), and 152 (W152R) in the NTD, and each one of these mutations individually afforded an ~1,000-fold increase in the neutralization IC50 values.
Result: Specifically, the sera showed a drop of 3.5-fold (Y145D) to 16-fold (K150E and W152R) in their neutralization I
SARS_CoV_2 mutation literature information.
PMID: 
2022
Biomedicine & pharmacotherapy
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