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 SARS_CoV_2 mutation literature information.


  Emergence of a novel SARS-CoV-2 Pango lineage B.1.1.526 in West Bengal, India.
 PMID: 34896696       2022       Journal of infection and public health
Table: W45L


  Comparative mutational analysis of SARS-CoV-2 isolates from Pakistan and structural-functional implications using computational modelling and simulation approaches.
 PMID: 34968862       2022       Computers in biology and medicine
Result: Interestingly, in Pakistani SARS-COV-2 isolates, a new mutation in ORF8, W45L was observed in the present study, while 35 out of 50 isolates have the ORF8-L genotype.
Table: W45L


  Variations in Orf3a protein of SARS-CoV-2 alter its structure and function.
 PMID: 33527091       2021       Biochemistry and biophysics reports
Table: W45L


  SARS-CoV-2 Genome from the Khyber Pakhtunkhwa Province of Pakistan.
 PMID: 33748571       2021       ACS omega
Conclusion: However, E93K and W45L exhibited increased flexibility compared to
Conclusion: Point mutations (L84S, E93K, and W45L) in NS8 (ORF8) have a destabilizing effect on the structure.
Result: Among the three mutations (NS8_L84S, NS8_E92K, and NS8_W45L) in NS8 (ORF8) of SARS-CoV-2, the appearance of E92K has not been reported in earlier studies.


  Whole-genome sequencing of SARS-CoV-2 reveals the detection of G614 variant in Pakistan.
 PMID: 33755704       2021       PloS one
Result: Furthermore, strain NIH-45090 showed a missense mutation in ORF8 protein (a.a W45L), strain NIH-45143 revealed novel amino acid substitutions in ORF1ab polyprotein (a.a N3491K) and in ORF3a protein (a.a F105S).
Table: W45L


  Mutations in SARS-CoV-2 ORF8 Altered the Bonding Network With Interferon Regulatory Factor 3 to Evade Host Immune System.
 PMID: 34335535       2021       Frontiers in microbiology
Table: W45L
Figure: (A) ORF8 WT, (B) S24L, (C) W45L, (D) V62L, (E) L84S, (F) V62L, and L84S double mutant (G).
Figure: (C) Key hydrogen bonding interactions of the W45L complex with the IRF3 binding interface along with stick representation of the Figure: Superimposed structure of ORF8 WT (green) with S24L (light magenta), W45L (cyan), V62L (yellow), L84S (orange), and V62L, L84S (dark magenta).


  Coding-Complete Genome Sequences of Alpha and Delta SARS-CoV-2 Variants from Kamphaeng Phet Province, Thailand, from May to July 2021.
 PMID: 34854728       2021       Microbiology resource announcements
Table: W45L



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