literature

SARS_CoV_2 mutation literature information.

Reduced levels of convalescent neutralizing antibodies against SARS-CoV-2 B.1+L249S+E484K lineage.

PMID: 34780883 2022 Virus research

Result: Regarding B.1.111 isolates, although both share the mutation pattern characteristic of the B.1.111 lineage (Spike D614G, NS3 Q57H and NSP12 P323L), several divergent genome wide mutations were observed between those isolates, for example, EPI_ISL_794659 have two additional mutations at the S protein (Spike T859I and W152R) (Table 1).

Result: The isolate B.1.111-I is located close to the node defining the B.1.111 lineage, while B.1.111-II is placed in a monophyletic group along with more B.1.111 sequences containing the Spike mutation W152R, whic

Emergence and phenotypic characterization of the global SARS-CoV-2 C.1.2 lineage.

PMID: 35396511 2022 Nature communications

Result: Additional substitutions include P25L (in ~43% of viruses) and W152R (in ~7%) in the NTD, T478K (~17%) in the RBM, L585F (~17%) in S1, P681H (~8%) adjacent to the furin cleavage site, A879T (~7%), D936H (~5%), and H1101Q (~8%) in S2, with additional amino acid changes detected in less than 5% of viruses.

Mutational analysis in international isolates and drug repurposing against SARS-CoV-2 spike protein: molecular docking and simulation approach.

PMID: 34307771 2021 Virusdisease

Table: W152R

A Combination of Receptor-Binding Domain and N-Terminal Domain Neutralizing Antibodies Limits the Generation of SARS-CoV-2 Spike Neutralization-Escape Mutants.

PMID: 34607456 2021 mBio

Abstract: As seen with some of the natural VOC, the neutralization potencies of COVID-19 convalescent-phase sera were reduced by 4- to 16-fold against rVSV-SARS2 bearing Y145D, K150E, or W152R spike mutations.

Result: For the NTD MAb (ADI-56479), rVSV-SARS2 neutralization-escape mutations mapped to residues 145 (Y145D), 150 (K150E), and 152 (W152R) in the NTD, and each one of these mutations individually afforded an ~1,000-fold increase in the neutralization IC50 values.

Result: Specifically, the sera showed a drop of 3.5-fold (Y145D) to 16-fold (K150E and W152R) in their neutralization I

A rigorous framework for detecting SARS-CoV-2 spike protein mutational ensemble from genomic and structural features.

PMID: 34806033 2021 Current research in structural biology

Result: Specifically, L18F, T19R, and T20N are present in the N-terminus epitope, whereas G142D, W152 R/L/C, M153T, and F157 are present in the supersite beta-hairpin epitope.

Molecular Characterization of Severe Acute Respiratory Syndrome Coronavirus 2 Isolates From Central Inner Sardinia.

PMID: 35095827 2021 Frontiers in microbiology

Table: p.Trp152Arg

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