literature

SARS_CoV_2 mutation literature information.

Tracking SARS-CoV-2 Spike Protein Mutations in the United States (2020/01 - 2021/03) Using a Statistical Learning Strategy.

PMID: 34159336 2021 bioRxiv

Result: The S13I and W152C mutations, which are situated in the N-terminal domain (NTD) of the Spike protein, have been implicated in escape from NTD-targeting monoclonal antibodies.

Result: The VRV-haplotype S13I-W152C-L452R (ICR-3) appeared in Fall 2020 and is rapidly becoming dominant in states on the West Coast, as well as appearing in selected Southwestern and Southeastern states.

The Emergence and Spread of Novel SARS-CoV-2 Variants.

PMID: 34409009 2021 Frontiers in public health

Result: The mutations of S protein include S13I, W152C, and L452R.

Immune Evasion of SARS-CoV-2 Emerging Variants: What Have We Learnt So Far?

PMID: 34206453 2021 Viruses

Introduction: This variant (Epsilon) comprises two separate lineages B.1.427 and B.1.429, the first carrying two spike mutations (L452R, D614G) and the second carrying four (S13I, W152C, L452R, D614G).

Anti-SARS-CoV-2 Vaccines and Monoclonal Antibodies Facing Viral Variants.

PMID: 34207378 2021 Viruses

Introduction: It derives from the B line (B.1.429 and B.1.427) and carries three mutations on the Spike: S13I, W152C, and, most notably, L452R, located in the RBD and potentially involved in mAbs neutralization escape (Table 1).

SARS-CoV-2 immune evasion by the B.1.427/B.1.429 variant of concern.

PMID: 34210893 2021 Science (New York, N.Y.)

Abstract: A novel variant of concern (VOC) named CAL.20C (B.1.427/B.1.429), which was originally detected in California, carries spike glycoprotein mutations S13I in the signal peptide, W152C in the N-terminal domain (NTD), and L452R in the receptor-binding domain (RBD).

Abstract: The S13I and W152C mutations resulted in total loss of neutralization for 10 of 10 NTD-specific mAbs because the NTD antigenic supersite was remodeled by a shift of the signal peptide cleavage site and the formation of a new disulfide bond, as revealed by mass spectrometry and structural studies.

The challenge of screening SARS-CoV-2 variants of concern with RT-qPCR: One variant can hide another.

PMID: 34332998 2021 Journal of virological methods

Abstract: From week 18 we used in addition the new NovaplexSARS-CoV-2 Variants II Assay for samples with no targets found with the Variants I assay or with the mutation E484K alone, in order to screen the mutations L452R, K417N/T and W152C.

Abstract: Of these, 47 had the L452R mutation without the W152C mutation, typical in the B.1.617 variant.

Discussion: Since early May 2021, a new NovaplexSARS-CoV-2 Variants II Assay has been available on the market to detect L452R, K417N, K417T and

Conformational Variability Correlation Prediction of Transmissibility and Neutralization Escape Ability for Multiple Mutation SARS-CoV-2 Strains using SSSCPreds.

PMID: 34337269 2021 ACS omega

Introduction: In January 2021, novel strains B.1.427/429, which contain S13I, W152C, L452R, and D614G mutations in the spike protein, were found in California (Figure 1A).

Detection and characterization of the SARS-CoV-2 lineage B.1.526 in New York.

PMID: 34373458 2021 Nature communications

Table: W152C

Acquisition of the L452R Mutation in the ACE2-Binding Interface of Spike Protein Triggers Recent Massive Expansion of SARS-CoV-2 Variants.

PMID: 34379531 2021 Journal of clinical microbiology

Result: According to genomic analysis, the epsilon variant has also been defined by 4 additional amino acid mutations, including two spike protein mutations, S13I and W152C, located in the signal peptide and N-terminal domain, respectively.

Result: Both S13I and W152C mutations were found in 10 nonduplicative samples, suggesting their identity with the epsilon variant.

Result: In sharp contrast, the variants without S13I/W152C mutations formed a distinct phylogenetic clade that is distant from the epsilon variants and shared none of the epsilon variant-specific mutations.

Table: W152C

Discussion: Interestingly, the same study showed that the L452R-Positive SARS-CoV-2 Omicron Variant, Northern Lombardy, Italy.

PMID: 34379531 2021 Journal of clinical microbiology

Result: It was originally reported that, besid

Result: To determine how closely the L452R variants without S13I and W152C mutations were related to the epsilon variant, full-genome sequencing was performed on three of those samples and on four L452R samples with S13I and W152C.

Discussion: This would indicate that other mutations in the epsilon variant, such as S13I and W152C in the N-terminal domain of the spike protein, might enhance the adaptive impact of L452R, i.e., that the genomic background of L452R plays a significant role as the target of positive selection.

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