Introduction: It derives from the B line (B.1.429 and B.1.427) and carries three mutations on the Spike: S13I, W152C, and, most notably, L452R, located in the RBD and potentially involved in mAbs neutralization escape (Table 1).
SARS-CoV-2 immune evasion by the B.1.427/B.1.429 variant of concern.
Abstract: A novel variant of concern (VOC) named CAL.20C (B.1.427/B.1.429), which was originally detected in California, carries spike glycoprotein mutations S13I in the signal peptide, W152C in the N-terminal domain (NTD), and L452R in the receptor-binding domain (RBD).
Abstract: The S13I and W152C mutations resulted in total loss of neutralization for 10 of 10 NTD-specific mAbs because the NTD antigenic supersite was remodeled by a shift of the signal peptide cleavage site and the formation of a new disulfide bond, as revealed by mass spectrometry and structural studies.
The challenge of screening SARS-CoV-2 variants of concern with RT-qPCR: One variant can hide another.
PMID: 34332998
2021
Journal of virological methods
Abstract: From week 18 we used in addition the new NovaplexSARS-CoV-2 Variants II Assay for samples with no targets found with the Variants I assay or with the mutation E484K alone, in order to screen the mutations L452R, K417N/T and W152C.
Abstract: Of these, 47 had the L452R mutation without the W152C mutation, typical in the B.1.617 variant.
Discussion: Since early May 2021, a new NovaplexSARS-CoV-2 Variants II Assay has been available on the market to detect L452R, K417N, K417T and
Discussion: The other two targets of the Variant II Assay are the L452R and W152C mutations.
Conformational Variability Correlation Prediction of Transmissibility and Neutralization Escape Ability for Multiple Mutation SARS-CoV-2 Strains using SSSCPreds.
Introduction: In January 2021, novel strains B.1.427/429, which contain S13I, W152C, L452R, and D614G mutations in the spike protein, were found in California (Figure 1A).
Detection and characterization of the SARS-CoV-2 lineage B.1.526 in New York.
Acquisition of the L452R Mutation in the ACE2-Binding Interface of Spike Protein Triggers Recent Massive Expansion of SARS-CoV-2 Variants.
PMID: 34379531
2021
Journal of clinical microbiology
Table: W152C
Discussion: Interestingly, the same study showed that the S13I and W152C mutations that are present in the S protein of the California-dominating B.1.427/B.1.429 lineage, but absent in CAL.20A, resulted in total loss of neutralization by all 10 N-terminal domain (NTD)-specific monoclonal antibodies te
Discussion: This would indicate that other mutations in the epsilon variant, such as S13I and W152C in the N-terminal domain of the spike protein, might enhance the adaptive impact of L452R, i.e., that the genomic background of L452R plays a significant role as the target of positive selection.
GB-2 blocking the interaction between ACE2 and wild type and mutation of spike protein of SARS-CoV-2.
Discussion: For epsilon variant, the two B.1.427 and B.1.429 lineages have the same spike protein mutations, inclunding S13I and W152C in the NTD and L452R in the RBD.
Estimation of secondary household attack rates for emergent SARS-CoV-2 variants detected by genomic surveillance at a community-based testing site in San Francisco.
Abstract: Certain viral lineages bearing spike mutations, defined in part by L452R, S13I, and W152C, comprised 54.9% of the total sequences from January, compared to 15.7% in November.
Result: We observed SARS-CoV-2 genome sequences that belonged to PANGO lineages B.1.427 and B.1.429, both of which share a trio of recent mutations in the spike protein (S13I, W152C, and L452R) (Figure 2).
SARS_CoV_2 mutation literature information.
PMID: 
2021
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