literature

SARS_CoV_2 mutation literature information.

Contribution of single mutations to selected SARS-CoV-2 emerging variants spike antigenicity.

PMID: 34536797 2021 Virology

Result: Both its NTD mutations, S13I and W152C, were less efficiently recognized by plasma compared to D614G.

Result: This VOI has two NTD mutations, S13I and W152C, both of which did not significantly impact this interaction.

The in vitro and in vivo efficacy of CT-P59 against Gamma, Delta and its associated variants of SARS-CoV-2.

PMID: 34547629 2021 Biochemical and biophysical research communications

Table: W152C

Serum Neutralizing Activity of mRNA-1273 against SARS-CoV-2 Variants.

PMID: 34549975 2021 Journal of virology

Table: W152C

SARS-CoV-2 Virus-Host Interaction: Currently Available Structures and Implications of Variant Emergence on Infectivity and Immune Response.

PMID: 34639178 2021 International journal of molecular sciences

Abstract: These include mutations S13I and

Conclusion: These include mutations S13I and W152C, decreasing antibody binding, N460K, increasing RDB affinity, or Q498R, positively affecting both properties .

Conclusion: These include mutations S13I and W152C, decreasing antibody binding, N460K, increasing RDB affinity, or Q498R, positively affecting both properties.

Temporal-Geographical Dispersion of SARS-CoV-2 Spike Glycoprotein Variant Lineages and Their Functional Prediction Using in Silico Approach.

PMID: 34700382 2021 mBio

Result: Dual mutants containing D614G and other amino acid changes, including those under positive selection or observed in VOCs (L5F, L18F, S98F, W152L/C, E154K, L222V, and A262S in S1-NTD; N439K, L452Q/R, S477N, L478R/K, E484K/Q, N501Y, and A570D within S1-RBD; Q677H/P and P681H/R in S1-CTD; T716I,

Re-emergence of Gamma-like-II and emergence of Gamma-S:E661D SARS-CoV-2 lineages in the south of Brazil after the 2021 outbreak.

PMID: 34789293 2021 Virology journal

Discussion: A neutralizing antibody activity study using convalescent serum from patients or serum from vaccinated individuals showed a 3-sixfold reduction against the B.1.429 variant, and furthermore, the neutralizing activity of mAbs targeting NTD was completely blocked due to the combined mutations S:S13I and S:W152C in that domain.

Discussion: Additional information from the GISAID (GISAID:2021-06-01) showed that the S: Discussion: The infective capacities of mutations occurring in the B.1.429 variant were investigated using pseudoviruses carrying the D614G mutation together with the L452R or W152C mutations infected in 293 T cells expressing the ACE2 receptor as well as the cofactor TMPRSS2.

SARS-CoV-2 Delta (B.1.617.2) Variant: A Unique T478K Mutation in Receptor Binding Motif (RBM) of Spike Gene.

PMID: 34796036 2021 Immune network

Table: W152C

A rigorous framework for detecting SARS-CoV-2 spike protein mutational ensemble from genomic and structural features.

PMID: 34806033 2021 Current research in structural biology

Result: Specifically, L18F, T19R, and T20N are present in the N-terminus epitope, whereas G142D, W152 R/L/C, M153T, and F157 are present in the supersite beta-hairpin epitope.

Phylogenomics and population genomics of SARS-CoV-2 in Mexico during the pre-vaccination stage reveals variants of interest B.1.1.28.4 and B.1.1.222 or B.1.1.519 and the nucleocapsid mutation S194L associated with symptoms.

PMID: 34846283 2021 Microbial genomics

Result: With only 25 sequences available, this analysis also identified covariances between S13I, L452R and W152C of the VOI B.1.427/9.

Tracking SARS-CoV-2 Spike Protein Mutations in the United States (January 2020-March 2021) Using a Statistical Learning Strategy.

PMID: 35062214 2021 Viruses

Result: The S13I and W152C mutations, which are situated in the N-terminal domain (NTD) of the Spike protein, have been implicated in escape from NTD-targeting monoclonal antibodies.

Result: The VRV-haplotype S13I-W152C-L452R (ICR-3) appeared in Fall 2020 and is rapidly becoming dominant in states on the West Coast, as well as appearing in selected southwestern and southeastern states (Figure 3C-F).

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