literature

SARS_CoV_2 mutation literature information.

SARS-CoV-2 Mutations and Their Impact on Diagnostics, Therapeutics and Vaccines.

PMID: 35273977 2022 Frontiers in medicine

Introduction: In addition, some of the notable substitutions in NTD are R246I (in B.1.351), W152C (in B.1.429), L18F (in B.1.351 and P.1), T19R (in B.1.17 and B.1.617) and G142D (in B.1.617 lineages), all of which are associated with immune-escape.

Longitudinal analysis of SARS-CoV-2 spike and RNA-dependent RNA polymerase protein sequences reveals the emergence and geographic distribution of diverse mutations.

PMID: 34801754 2022 Infection, genetics and evolution

Result: 5D) share the same set of mutations on the spike protein (S13I, W152C, L452R), and have similar effect on transmissibility and antibody evasion.

Result: S13I and L452R were detected separately in previous sequences, but W152C was not.

Fig

Haplotype distribution of SARS-CoV-2 variants in low and high vaccination rate countries during ongoing global COVID-19 pandemic in early 2021.

PMID: 34848355 2022 Infection, genetics and evolution

Table: W152C

Efficacy of mRNA, adenoviral vector, and perfusion protein COVID-19 vaccines.

PMID: 34906769 2022 Biomedicine & pharmacotherapy

Table: W152C

Pan-SARS neutralizing responses after third boost vaccination in non-human primate immunogenicity model.

PMID: 35101265 2022 Vaccine

Table: W152C

Estimation of Secondary Household Attack Rates for Emergent Spike L452R Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Variants Detected by Genomic Surveillance at a Community-Based Testing Site in San Francisco.

PMID: 33788923 2022 Clinical infectious diseases

Abstract: Certain viral lineages bearing spike mutations, defined in part by L452R, S13I, and W152C, comprised 54.4% of the total sequences from January, compared to 15.7% in November.

Misidentification of the SARS-CoV-2 Mu variant using commercial mutation screening assays.

PMID: 35194675 2022 Archives of virology

Introduction: Any other mutation combination or the absence of any mutations required the use of a second rRT-PCR mutation assay, Allplex SARS-CoV-2 Variants II Assay (Seegene, Korea), which screens for the mutations K417N, K417T, L452R, and W152C.

Introduction: Following the scheme described above, in August 2021, we detected three strains that presented K417N, N501Y, and E484K mutations but did not present delH69/V70, W152C, K417T, L452R, or V1176F mutations.

Comparative Analysis of Five Multiplex RT-PCR Assays in the Screening of SARS-CoV-2 Variants.

PMID: 35208761 2022 Microorganisms

Abstract: Th

Method: Five RUO multiplex real-time qualitative RT-PCR assays targeting some of the most widespread mutations in the spike protein (i.e., L452R, W152C, K417T, K417N, E484Q, E484K, N501Y) were used on positive specimens for a rapid and presumptive detection of the SARS-CoV-2 variants (Figure 1 and Table 1).

Method: The SARS-CoV-2 Variants II Assay is a multiplex RT-PCR assay for the detection of spike protein mutations L452R, W152C, K417T and K417N, and it is validated for lower and upper respiratory tract specimens.

Serum Neutralizing Activity of mRNA-1273 against SARS-CoV-2 Variants.

PMID: 34549975 2021 Journal of virology

Table: W152C

Contribution of single mutations to selected SARS-CoV-2 emerging variants spike antigenicity.

PMID: 34536797 2021 Virology

Result: Both its NTD mutations, S13I and W152C, were less efficiently recognized by plasma compared to D614G.

Result: This VOI has two NTD mutations, S13I and W152C, both of which did not significantly impact this interaction.