Abstract: Importantly, the number of patients infected with the V354F and V470A mutants has increased with the development of the SARS-CoV-2 pandemic.
Abstract: We identified two spike-S1 point mutations (V354F and V470A) by receptor-ligand docking and binding enzyme-linked immunosorbent assays.
Method: Two point mutants (V354F and V470A) were constructed by site-directed mutagenesis, and the vectors were transfected into HEK293 cells.
Re
Result: According to interaction energy analysis, SARS-CoV-2 strains with the spike-S1 V354F or V470A substitutions were likely novel strains with increased infectivity (Figures 4D, 5A).
SARS_CoV_2 mutation literature information.
PMID: 
2021
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