literature

Vaccine-escape and fast-growing mutations in the United Kingdom, the United States, Singapore, Spain, India, and other COVID-19-devastated countries.

PMID: 34004284 2021 Genomics

Conclusion: While mutations Q493R, R408I, Q493H, P384S, and N501T can also be disruptive, but mutations N439K, V367F, and S477R are not as disruptive as other rapidly growing ones.

Result: Moreover, mutations V367F, E484K, N354D, and S373L with positive BFE changes also have a relatively higher mutation rate since early 2021, indicating that these four mutations may strengthen the binding of ACE2 and the S protein RBD, and potentially increase the infectivity of SARS-CoV-2.

Table:

PMID: 34013346 2021 Briefings in bioinformatics

Conclusion: Two mutants, V367F and N354D/D364Y, were predicted to have significantly higher binding affinities, and the prediction was validated by experiment and the virus epidemiology.|

Result: The simulation results suggested that all the three mutants (N354D/D364Y, V367F and W436R) can enhance the binding between spike RBD and hACE2, which agrees with the experiment.

Result: Two of these three mutants, N354D/D364Y and V367F, have drawn extensive attention as they showed up in multiple countries, indicating its enhanced binding affinity in the real world.

A core-shell structured COVID-19 mRNA vaccine with favorable biodistribution pattern and promising immunity.

PMID: 34059617 2021 Signal transduction and targeted therapy

Discussion: Although some of the mutations occurred in RBD region such as V367F, G476S, V483A, SW0123-elicited Abs were still able to neutralize these variants effectively, which suggested that diversified NAbs and non-RBD region functional Abs can be induced.

Machine Learning Reveals the Critical Interactions for SARS-CoV-2 Spike Protein Binding to ACE2.

PMID: 34086459 2021 The journal of physical chemistry letters

Introduction: As expected, several mutations that were observed initially yet never became widespread, namely, G476S, V483A, and V367F, had negligible or slightly detrimental effects on binding to ACE2 (Table 2).

Introduction: Such is the case, for example, for G476S, V483A, and V367F.

Table: V367F

Large scale genomic analysis of 3067 SARS-CoV-2 genomes reveals a clonal geo-distribution and a rich genetic variations of hotspots mutations.

PMID: 33170902 2020 PloS one

Discussion: Eight stains from china, USA and France harbored V367F mutation previously described to enhance the affinity with ACE2 receptor.

SARS-CoV-2 gene content and COVID-19 mutation impact by comparing 44 Sarbecovirus genomes.

PMID: 33024961 2020 Research square

Result: Another three are in moderately-conserved contexts (V367F, D839Y/N/E, D936Y/H) less likely to be functional, and eight lie in repeatedly-altered amino acids in poorly-conserved regions and likely-neutral.

Variations in SARS-CoV-2 Spike Protein Cell Epitopes and Glycosylation Profiles During Global Transmission Course of COVID-19.

PMID: 33013929 2020 Frontiers in immunology

Result: Binding level results of T29I, V367F, A706V, and A831V demonstrated that these substitutions had low binding affinity in HLA-A01:01, HLA-B07:02, and HLA-B35:01 compared to the wild type, while H49Y, Q239K, V483A, D839Y, S943P, A1078S, and P1263L substitutions still had strong binding affinity with HLA molecules.

Result: For variant S proteins, T29I, H49Y, Q239K, V367F,

Table: V367F

SARS-CoV-2 gene content and COVID-19 mutation impact by comparing 44 Sarbecovirus genomes.

PMID: 32577641 2020 bioRxiv

Result: First, we investigated Sarbecovirus conservation of 14 amino acids in the spike protein in which mutations appear to be accumulating in the SARS-CoV-2 population, namely D614G, L5F, L8V/W, H49Y, Y145H, Q239K, V367F, G476S, V483A, V615I/F, A831V, D839Y/N/E, S943P, P1263L.

Mutations in SARS-CoV-2 Leading to Antigenic Variations in Spike Protein: A Challenge in Vaccine Development.

PMID: 32884216 2020 Journal of laboratory physicians

Abstract: The RBD T323I, A344S, V367F, A419S, A522S and K529E are novel mutations reported first time in this study.

Abstract: The significant variations in the predicted epitopes showing high antigenicity were A348V, V367F and A419S in receptor binding domain (RBD).

Result: Furthermore, the evaluation of the antigenicity of spike protein predicted 14 highest scoring antigenic epitopes (antigenic scores >= 1.0) due to variations in each (at positions Table: V367F

Variant analysis of SARS-CoV-2 genomes.

PMID: 32742035 2020 Bulletin of the World Health Organization

Result: Among the variants in the receptor binding domain, V483A (26 samples), G476S (9 samples) and V367F (12 samples) are highly recurrent.

Discussion: V483A and G476S are primarily observed in samples from the United States, whereas V367F is found in samples from China, Hong Kong Special Administrative Region, France and the Netherlands.

Discussion: The V367F and D364Y variants have been reported to enhance the structural stability of the spike protein facilitating more efficient binding to the ACE2 receptor.