literature

SARS_CoV_2 mutation literature information.

SARS-CoV-2 mutations acquired during serial passage in human cell lines are consistent with several of those found in recent natural SARS-CoV-2 variants.

PMID: 35474907 2022 Computational and structural biotechnology journal

Result: There were also several sporadic mutations (I76T, V367F, I468V, S685R, A694V, S813I, Q992H, and T1076A) in one of the viruses analyzed in this study.

Spike protein cleavage-activation mediated by the SARS-CoV-2 P681R mutation: a case-study from its first appearance in variant of interest (VOI) A.23.1 identified in Uganda.

PMID: 34230931 2022 bioRxiv

Abstract: The A.23 viral lineage, characterized by three spike mutations F157L, V367F and Q613H, was first identified in COVID-19 cases from a Ugandan prison in July 2020, and then was identified in the general population with additional spike mutations (R102I, L141F, E484K and P681R) to comprise lineage A.23.1 by September 2020, with this virus being designated a variant of interest (VOI) in Africa and with subsequent spread to 26 other countries.

Introduction: Within lineage A, the A.23 viral lineage, was first identified in a Ugandan prison in July 2020, and was characterized by three spike mutations

E484K and N501Y SARS-CoV 2 spike mutants Increase ACE2 recognition but reduce affinity for neutralizing antibody.

PMID: 34915409 2022 International immunopharmacology

Introduction: Using a large-scale genomic screening pipeline, my group previously identified two spike mutants, V367F and S494P, with enhanced human ACE2 binding ability.

Table: V367F

Computational investigation reveals that the mutant strains of SARS-CoV2 have differential structural and binding properties.

PMID: 34968787 2022 Computer methods and programs in biomedicine

Abstract: Furthermore, the binding strength of different MTs along with WT (wildtype) was revealed that MTs showed differential binding affinities to host protein with high binding strength exhibited by V367F and V483A MTs.

Introduction: Moreover, RBD MTs such as V367F and V483A showed high binding affinities to the host ACE2 receptor protein.

Introduction: The rest of mutations V367F and R408I, mostly affected the overall topology and stability of RBD as these mutations present at the loop regions of N-terminal and turn that connect beta-sheet3 and 4, respectively.

Aggregation of high-frequency RBD mutations of SARS-CoV-2 with three VOCs did not cause significant antigenic drift.

PMID: 35032057 2022 Journal of medical virology

Result: D614G + P384L + A522S and D614G + V367F + P384L + A522S also had a significantly higher neutralization effect on the mAbs compared with the D614G variant pseudovirus, suggesting the possible synergistic effec

Result: Alpha+S494P and Alpha+V367F also enhanced infectivity within fourfold (Figure 2A).

Result: Among the possible Beta variants, the Beta+V367F pseudovirus variant showed nearly fourfold enhanced infectivity, especially in Huh7 and LLC-MK2 cells, and Beta+S494P and Beta+A520S showed similar effects (Figure 2B).

Emerging Vaccine-Breakthrough SARS-CoV-2 Variants.

PMID: 35133792 2022 ACS infectious diseases

Table: V367F

Detection and characterization of the SARS-CoV-2 lineage B.1.526 in New York.

PMID: 34373458 2021 Nature communications

Table: V367F

Bioinformatics Analysis Unveils Certain Mutations Implicated in Spike Structure Damage and Ligand-Binding Site of Severe Acute Respiratory Syndrome Coronavirus 2.

PMID: 34121839 2021 Bioinformatics and biology insights

Result: In addition, mutations more than 3 were found, such as L54F (40 mutations), R78M (15 mutations), V367F (5 mutations), A829T (10 mutations), H1083Q (4 mutations), T791I (12 mutations), Q677H (4 mutations), E583D (15 mutations), T572I (10 mutations), and L8V (4 mutations).

Table: V367F

Cross-neutralization of RBD mutant strains of SARS-CoV-2 by convalescent patient derived antibodies.

PMID: 34379353 2021 Biotechnology journal

Result: As shown in Figure 4a, HTS0422, HTS0433 and HTS0446 bind with both wildtype and mutant (N501Y, W463R, N354D, V367F, both N354D and D364Y) RBD significantly.

Result: As shown in Figure 6a, the infection of mutants N354D, V367F and N354D/D364Y could be inhibited by all 4 antibodies.

Result: In this study, six different SARS-CoV-2 RBD mutants (N501Y, R408I, W463R, N354D, V367F an

Potent prophylactic and therapeutic efficacy of recombinant human ACE2-Fc against SARS-CoV-2 infection in vivo.

PMID: 34385423 2021 Cell discovery

Abstract: hACE2-Fc also neutralized various SARS-CoV-2 strains with enhanced infectivity including D614G and V367F mutations, as well as the emerging SARS-CoV-2 variants, B.1.1.7 (Alpha), B.1.351 (Beta), B.1.617.1 (Kappa), and B.1.617.2 (Delta), demonstrating its potent and broad-spectrum antiviral effects.

Method: In brief, HEK293 cells were co-transfected with reporter plasmid plenti-GFP-luc, packaging plasmid psPAX2, and coronavirus spike plasmid of interest (pcDNA3.1-SARS-CoV-S, pcDNA3.1-SARS-CoV-2-S, pcDNA3.1-SARS-CoV-2-S-D614G, pcDNA3.1-SARS-CoV-2-S-V367F, pcDNA3.1-B.1.1.7-S, pcDNA3.1-B.1.351-S, pcDNA3.1-B.1

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