Result: In addition, epidemiological and evolutionary data for
H36Y,
N341D,
D351Y, and
V354F of
spike-S1,
G251V of
ORF3a,
V62L and
L84S of
ORF8, and
S194L and
S202N of
nucleocapsid phosphoprotein were analyzed.
Discussion: Here, we found that SARS-CoV-2 with
V354F or
V470A substitutions of
spike-S1 showed increased infectivity.