Introduction: IGHV3-53 and IGHV3-66, which differ by only one conservative substitution V12I, and IGHV1-2 are the most enriched IGHV genes used among 1,593 RBD antibodies from 32 studies (Figure 1B).
Structural and functional ramifications of antigenic drift in recent SARS-CoV-2 variants.
Introduction: Certain IGHV genes are highly enriched in the antibody response to SARS-CoV-2 infection, with IGHV3-53 and IGHV3-66, which differ by only one conservative substitution (V12I), and IGHV1-2 being the most enriched IGHV genes used among 1,593 RBD-targeting antibodies from 32 studies .
SARS_CoV_2 mutation literature information.
PMID: 
2021
bioRxiv
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