literature

SARS_CoV_2 mutation literature information.

Analysis of SARS-CoV-2 variant mutations reveals neutralization escape mechanisms and the ability to use ACE2 receptors from additional species.

PMID: 34166623 2021 Immunity

Method: The variant P.1 (GISAID: EPI_ISL_792681) was constructed with 12 mutations including L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, D614G, H655Y, T1027I and V1176F.

A Novel SARS-CoV-2 Viral Sequence Bioinformatic Pipeline Has Found Genetic Evidence That the Viral 3' Untranslated Region (UTR) Is Evolving and Generating Increased Viral Diversity.

PMID: 34234758 2021 Frontiers in microbiology

Result: The A222V change is predicted to decrease the motility of the N-terminal of Spike protein (NTD), while the S477N and V1176F variants are predicted to increase the motility of the Receptor Binding Domain (RBD) and Stalk domain of the Spike protein, respectively (Figure 2E).

Result: Two spike protein substitutions from European outbreaks containing Ala > Val (A222V, viral frequency = 17%) and Ser > Asn (S477N, viral frequency = 6.2%) including one Val > Phe substitution from a Brazilian outbreak (V1176F, viral frequency = 0.22%) readily changed

PMID: 34241897 2021 Journal of medical virology

Result: We additionally observed the D614G mutation in the spike, as well as the mutation G25088T (V1176F).

Result: We also highlight the presence of the two mutations:D614G and V1176F:in the spike gene in all analyzed P.1 and P.2 variants of this study.

Updated SARS-CoV-2 single nucleotide variants and mortality association.

PMID: 34245452 2021 Journal of medical virology

Abstract: Our logistic regression model explored features contributing to mortality status, including three critical SNVs, G25088T(S:V1176F), T27484C (ORF7a:L31L), and T25A (upstream of ORF1ab), ages above 40 years old, and the male gender.

Result: After nonsignificantly correlated features (p > 0.001) were filtered out, the logit of the death event can be predicted based on the following features: three SNVs enriched in death group, including G25088T(S:V1176F), T27484C (ORF7a:L31L), an

Evolutionary Tracking of SARS-CoV-2 Genetic Variants Highlights an Intricate Balance of Stabilizing and Destabilizing Mutations.

PMID: 34281387 2021 mBio

Abstract: We recorded persistence of D614G, S477N, A222V, and V1176F variants and a global expansion of the PANGOLIN variant B.1.

Table: V1176F

Discussion: Our analysis confirmed previously recorded positive natural selection of the D614G, S477N, A222V, and V1176F variants and a global expansion of the PANGOLIN variant B.1.

Ongoing global and regional adaptive evolution of SARS-CoV-2.

PMID: 34292871 2021 Proc Natl Acad Sci U S A

Result: Three of these signature mutations pass the strict criteria for positive selection:S N501Y, S S477N, and S V1176F:and S N501Y makes the shortlist of the 22 strongest candidates.

Mutational analysis in international isolates and drug repurposing against SARS-CoV-2 spike protein: molecular docking and simulation approach.

PMID: 34307771 2021 Virusdisease

Table: V1176F

Correlates of SARS-CoV-2 Variants on Deaths, Case Incidence and Case Fatality Ratio among the Continents for the Period of 1 December 2020 to 15 March 2021.

PMID: 34356077 2021 Genes

Result: The Spike_V1176F mutation was reported at 29.30% in SARS-CoV-2 genome sequences isolated from South America.

Mutation hotspots and spatiotemporal distribution of SARS-CoV-2 lineages in Brazil, February 2020-2021.

PMID: 34363852 2021 Virus research

Result: After the importation of B.1.1 lineages characterized by N:R203K and N:G204R mutations, community transmission massively occurred and gave rise to B.1.1.28 (S:V1176F) and B.1.1.33 lineages (ORF6:I33T and N:I292T), widely distributed in Brazilian regions along the first year of the pandemic.

Result: The G25088T (S:V1176F) replacement from B.1.1.28 occurred in 47.56% of all sequences, while T29148C (N:I292T) and

PMID: 34373458 2021 Nature communications

Table: V1176F

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