literature

SARS_CoV_2 mutation literature information.

Genomic surveillance reveals the detection of SARS-CoV-2 delta, beta, and gamma VOCs during the third wave in Pakistan.

PMID: 34726786 2021 Journal of medical virology

Table: V1176F

Association between prognostic factors and the outcomes of patients infected with SARS-CoV-2 harboring multiple spike protein mutations.

PMID: 34725366 2021 Scientific reports

Discussion: Interestingly, a previous report showed that one variant in non-RBD S protein, V1176F, might lead to RBD-ACE2 binding changes and was associated with a high mortality rate of COVID-19.

Temporal-Geographical Dispersion of SARS-CoV-2 Spike Glycoprotein Variant Lineages and Their Functional Prediction Using in Silico Approach.

PMID: 34700382 2021 mBio

Result: Twelve signature amino acid mutations (L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, D614G, H655Y, T1027I, and V1176F) were observed in the S protein as well as other consensus changes, including ORF1a (S1188L and K1795Q), ORF1b (P214L and E1164D), ORF3a (S253P),

PMID: 34696444 2021 Viruses

Method: All N501Y positive samples are further analyzed for the presence of K417N (88 bp) and V1176F (160 bp) mutations.

Method: For this purpose, RNA eluate of N501Y positive saliva samples is further analyzed by commercially available SNIP assays for K417N and V1176F presence (VirSNiP SARS-CoV-2 Spike K417N and VirSNiP SARS-CoV-2 Spike V1176F, TIB MolBio, Berlin, Germany).

Method: Sample is considered positive for K417N or V1176F when the melting curve analysis shows a Tm of 61 C (+-2 C) or 57.9 C (+-1 C) respectively.

Rapid Automated Screening for SARS-CoV-2 B.1.617 Lineage Variants (Delta/Kappa) through a Versatile Toolset of qPCR-Based SNP Detection.

PMID: 34679517 2021 Diagnostics (Basel, Switzerland)

Abstract: METHODS: We created a broad set of single nucleotide polymorphism (SNP)-assays including del-Y144/145, E484K, E484Q, P681H, P681R, L452R, and V1176F based on a highly specific multi-LNA (locked nucleic acid)-probe design to maximize mismatch discrimination.

Method: Based on previous works, for detecting del-HV69/70 and N501Y via RT-qPCR, we designed and tested further assays to be able to detect and discriminate all lineages currently holding VOC status (, accessed on 28 June 2021): del-Y144/145, E484K, E484Q, P681H, P681R, L452R, and

PMID: 34660520 2021 Frontiers in public health

Method: Next, in the set of genomes found, we verified all mutations, excluding those that define the B.1.1.28 lineage (C241T, F924F, P4715L, D614G, V1176F, R203K, R203R and G204R).

Ten emerging SARS-CoV-2 spike variants exhibit variable infectivity, animal tropism, and antibody neutralization.

PMID: 34645933 2021 Communications biology

Result: Moreover, although P.2 only has one additional mutation (V1176F) in the S2 domain, its neutralization activity was less reduced in the pseudovirus- and RBD protein-induced sera compared with the E484K single-mutation strain.

Evaluation of the clinical and analytical performance of the Seegene allplex SARS-CoV-2 variants I assay for the detection of variants of concern (VOC) and variants of interests (VOI).

PMID: 34628158 2021 Journal of clinical virology

Table: V1176F

Serum Neutralizing Activity of mRNA-1273 against SARS-CoV-2 Variants.

PMID: 34549975 2021 Journal of virology

Table: V1176F

Crucial Mutations of Spike Protein on SARS-CoV-2 Evolved to Variant Strains Escaping Neutralization of Convalescent Plasmas and RBD-Specific Monoclonal Antibodies.

PMID: 34484190 2021 Frontiers in immunology

Introduction: In addition, several recent studies have focused on the neutralizing activity of vaccine-elicited humoral immunity against new circulating mutant lineages, including B.1.1.7 (United Kingdom, bearing mutations 69-70 del, 144 del, N501Y, A570D, D614G, P681H, T716I, S982A, and D1118H in the spike protein), B.1.429 (United States, bearing mutations S13I, W152C, L452R, and D614G in the spike protein), B.1.351(South Africa, bearing mutations D80A, D215G,

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