literature

SARS_CoV_2 mutation literature information.

SARS-CoV-2 reinfection in a healthcare professional in inner Sao Paulo during the first wave of COVID-19 in Brazil.

PMID: 34425504 2021 Diagnostic microbiology and infectious disease

Abstract: Genomic analysis identified that primoinfection was caused by the endemic lineage B.1.1.33 while reinfection by the lineage B.1.1.44, a lineage with an additional V1176F mutation in S protein.

Conclusion: A remarkable difference found in B.1.1.44 is an additional V1176F substitution besides the highly disseminated D614G amino acid substitution prevalent worldwide; increased number of mutations in S protein are also reported in other reinfection episodes (Table 2).

Conclusion: In comparison with the WIV04-sequence, mutations were identified in S, N and NSP proteins of both genomes, but reinfection case (lineage B.1.44) presented an additional V1176F mutation in S

Epitope diversity of SARS-CoV-2 hyperimmune intravenous human immunoglobulins and neutralization of variants of concern.

PMID: 34430803 2021 iScience

Method: Antibody preparations were evaluated by SARS-CoV-2 pseudovirus neutralization assay (PsVNA) using WA-1 strain, UK variant (B.1.1.7 with spike mutations: H69-V70del, Y144del, N501Y, A570D, D614G, P681H, T716I, S982A, and D1118H), SA variant (B.1.351 strain with spike mutations L18F, D80A, D215G, L242-244del, R246I, K417N, E484K, N501Y, D614G, and

ACE2-targeting monoclonal antibody as potent and broad-spectrum coronavirus blocker.

PMID: 34433803 2021 Signal transduction and targeted therapy

Method: P.1: L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, D614G, H655Y, T1027I, V1176F.

An Autochthonous Outbreak of the SARS-CoV-2 P.1 Variant of Concern in Southern Italy, April 2021.

PMID: 34449757 2021 Tropical medicine and infectious disease

Introduction: These amino acid changes are L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, H655Y, T1027I, and V1176F.

Evolution, Mode of Transmission, and Mutational Landscape of Newly Emerging SARS-CoV-2 Variants.

PMID: 34465019 2021 mBio

Table: V1176F

Dynamics prediction of emerging notable spike protein mutations in SARS-CoV-2 implies a need for updated vaccines.

PMID: 34508827 2021 Biochimie

Method: The chosen sequences of single mutations included the following amino acid substitutions: L5F, L18F, D80A, S98F, A222V, A262S, P272L, K417 N, N439K, L452R, Y453F, S477 N, E484K, E484Q, N501T, N501Y, E583D, D614G, Q675H, Q675P, Q677H,

PMID: 32950697 2020 Infection, genetics and evolution

Result: The most frequent in S were D614G (83%) V1176F (2.2%) and P1263L (1.5%), while the most frequent in N were R203K (34.5%), G204R (34.3%), I292T (15.8%) and S197L (3.3%).

Coding-Complete Genome Sequences of 23 SARS-CoV-2 Samples from the Philippines.

PMID: 33093050 2020 Microbiology resource announcements

Introduction: Five substitutions (ORF1a-R226K, ORF1a-E1126K, ORF1a-L3930F, S-V1176F, and ORF7b-V21I) were observed uniquely in 2 sequences of lineage B.1.1.28.

Table: V1176F

SARS-CoV-2 genomic and quasispecies analyses in cancer patients reveal relaxed intrahost virus evolution.

PMID: 32869023 2020 bioRxiv

Result: Another 85 SNVs were observed in our sequences in a lower frequency (1.4-19.7%; S2 Table), including nine non-synonymous mutations in S protein (V16F, V367L, K558N, Q675H, A879V, S939F, V1176F, K1191N and G1219V).

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