Result: Another 85 SNVs were observed in our consensus sequences at lower frequency (1.4%-19.7%; Supplementary Table S2), including nine non-synonymous mutations in S protein (V16F, V367L, K558N, Q675H, A879V, S939F, V1176F, K1191N, and G1219V).
Method: The P.1 virus used in these studies contained the following mutations: L18F, T20N, P26S, D138Y, R190S, K417T, E464K, N501Y, D614G, H655Y, T1027I, V1176F.
Result: Compared to the Wuhan sequence, P.1 contains the following mutations: L18F, T20N, P26S, D138Y, and R190S in the NTD; K417T, E484K, and PMID: 33908339
2021
Epidemiology and infection
Result: However, during the second wave starting from October 2020 substitution point mutations E780Q, K417N, T478I, N501Y, E484K, N439K, V1176F, S477N and A222V became common at spike protein in the isolates in Japan.
Table: V1176F
Mutation Signatures and In Silico Docking of Novel SARS-CoV-2 Variants of Concern.
Result: The BR-VOC is highly mutated in the S-gene resulting in 12 aa substitutions in the S-protein including L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, D614G, H655Y, T1027I, and V1176F.
SARS-CoV-2 mutations: the biological trackway towards viral fitness.
Abstract: RESULTS: We provided a comprehensive view of mutations from a representative sampling from May to October 2020, highlighting two frequent mutations in spike glycoprotein (D614G and V1176F), an emergent mutation (E484K) in spike Receptor Binding Domain (RBD) characteristic of the B.1.351 and P.1 lineages, and the adjacent replacement of 2 amino acids in Nucleocapsid phosphoprotein (R203K and G204R).
E484K as an innovative phylogenetic event for viral evolution: Genomic analysis of the E484K spike mutation in SARS-CoV-2 lineages from Brazil.
PMID: 34044192
2021
Infection, genetics and evolution
Result: As B.1.1.28 is the ancestral lineage of P.1 and P.2, sequences from these three lineages harbor the G25088T (S:V1176F) mutation.
Result: Other mutations such as S:V1176F were not found only in N.9 (B.1.1.33.9) lineage.
Result: This genome combines all the prevalent substitutions D614G from spike protein, N:R203K, N:G204R, and Nsp12:P323L, allied to other very frequent mutations (S:V1176F, N:
An Epidemiological Analysis of SARS-CoV-2 Genomic Sequences from Different Regions of India.
Discussion: In addition, this study observed the presence of individual amino acid variants in the SARS-CoV-2 variants B.1.1.7 (S494P), B.1.525 (A67V, Q677H), B.1.526 (L5F, T95I, S477N), and P2 (V1176F) in the earlier samples.
SARS-CoV-2 Brazil variants in Latin America: More serious research urgently needed on public health and vaccine protection.
PMID: 34109031
2021
Annals of medicine and surgery (2012)
Introduction: These mutations are D614G and V1176F.
Introduction: These mutations are L18F, T20N, P26S, D138Y, R190S, D614G H655Y, T1027I, and V1176F.
Genome-wide association analysis of COVID-19 mortality risk in SARS-CoV-2 genomes identifies mutation in the SARS-CoV-2 spike protein that colocalizes with P.1 of the Brazilian strain.
Abstract: The locus at 25,088 bp is located in the P.1 strain, which later (April 2021) became one of the distinguishing loci (precisely, substitution V1176F) of the Brazilian strain as defined by the Centers for Disease Control.
Result: It is important to note that locus at 25,088 bp colocalizes with the P.1 variant that has become part of the CDC definition (precisely, substitution V1176F) of the Brazilian strain in April 2021 (UCSC Genome Browser on SARS-CoV-2, ).
Discussion: The V1176F mutation in S2 is located in the Heptad repeat 2 domain, which is involved in the viral fusion machinery.
SARS_CoV_2 mutation literature information.
PMID: 
2021
Virus evolution
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