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 SARS_CoV_2 mutation literature information.


  Evolutionary history of the SARS-CoV-2 Gamma variant of concern (P.1): a perfect storm.
 PMID: 35266951       2022       Genetics and molecular biology
Introduction: Currently, the WHO has identified the Gamma lineage (B.1.1.28.1, P.1 or Gamma; Nextstrain clade 20J/V3) with the following key S mutations: L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, D614G, H655Y, T1027I, and V1176F.


  A screening strategy for identifying the dominant variant of SARS-COV-2 in the fifth peak of Kurdistan- Iran population using HRM and Probe-based RT-PCR assay.
 PMID: 35271889       2022       Journal of virological methods
Table: V1176F


  SARS-CoV-2 Mutations and Their Impact on Diagnostics, Therapeutics and Vaccines.
 PMID: 35273977       2022       Frontiers in medicine
Table: V1176F


  Antigenicity comparison of SARS-CoV-2 Omicron sublineages with other variants contained multiple mutations in RBD.
 PMID: 35434713       2022       MedComm
Table: V1176F


  Evaluation of the clinical and analytical performance of the Seegene allplex SARS-CoV-2 variants I assay for the detection of variants of concern (VOC) and variants of interests (VOI).
 PMID: 34628158       2021       Journal of clinical virology
Table: V1176F


  Genomic surveillance reveals the detection of SARS-CoV-2 delta, beta, and gamma VOCs during the third wave in Pakistan.
 PMID: 34726786       2021       Journal of medical virology
Table: V1176F


  Evolution of SARS-CoV-2 Key Mutations in Vienna Detected by Large Scale Screening Program.
 PMID: 34696444       2021       Viruses
Method: All N501Y positive samples are further analyzed for the presence of K417N (88 bp) and V1176F (160 bp) mutations.
Method: For this purpose, RNA eluate of N501Y positive saliva samples is further analyzed by commercially available SNIP assays for K417N and V1176F presence (VirSNiP SARS-CoV-2 Spike K417N and VirSNiP SARS-CoV-2 Spike V1176F, TIB MolBio, Berlin, Germany).
Method: Sample is considered positive for K417N or V1176F when the melting curve analysis shows a Tm of 61 C (+-2 C) or 57.9 C (+-1 C) respectively.


  Temporal-Geographical Dispersion of SARS-CoV-2 Spike Glycoprotein Variant Lineages and Their Functional Prediction Using in Silico Approach.
 PMID: 34700382       2021       mBio
Result: Twelve signature amino acid mutations (L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, D614G, H655Y, T1027I, and V1176F) were observed in the S protein as well as other consensus changes, including ORF1a (S1188L and K1795Q), ORF1b (P214L and E1164D), ORF3a (S253P),  PMID: 34725366       2021       Scientific reports
Discussion: Interestingly, a previous report showed that one variant in non-RBD S protein, V1176F, might lead to RBD-ACE2 binding changes and was associated with a high mortality rate of COVID-19.


  In vitro selection of Remdesivir resistance suggests evolutionary predictability of SARS-CoV-2.
 PMID: 34534263       2021       PLoS pathogens
Method: There is phylogenetic uncertainty if V1176F was present in the ancestor preceding the formation of the Gamma (P.1) lineage, the deletion (Delta242-245; like other defining mutations) in Beta (B.1.351) is polymorphic.
Method: We further included the substitution observed in P1 (V1176F) and deletion in B1.351 (Delta242-245).



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