literature

SARS_CoV_2 mutation literature information.

Clinical and genomic data of sars-cov-2 detected in maternal-fetal interface during the first wave of infection in Brazil.

PMID: 35123044 2022 Microbes and infection

Result: An additional aa change was also present in S2 subunit HRP2 region (V1176F) of MT21774/2020 (Figure 3C).

Discussion: The V1176F aa change (MT21774 sequence) is located in the short S2 subunit, region involved in viral envelope fusion with cell membrane after ACE2-receptor binding, TMRPSS2 priming and endocytosis.

Longitudinal analysis of SARS-CoV-2 spike and RNA-dependent RNA polymerase protein sequences reveals the emergence and geographic distribution of diverse mutations.

PMID: 34801754 2022 Infection, genetics and evolution

Figure: L18F, E484K, N501Y, D614G, H655Y, and V1176F are associated with the Gamma variant of concern, and S13I, W152C, L452R are associated with the Epsilon variant of concern.

Discussion: The spike protein mutation V1176F results in increased stability of the spike protein and has also been associated with higher mortality rates.

Haplotype distribution of SARS-CoV-2 variants in low and high vaccination rate countries during ongoing global COVID-19 pandemic in early 2021.

PMID: 34848355 2022 Infection, genetics and evolution

Table: V1176F

Efficacy of mRNA, adenoviral vector, and perfusion protein COVID-19 vaccines.

PMID: 34906769 2022 Biomedicine & pharmacotherapy

Table: V1176F

Identification of genotypic variants and its proteomic mutations of Brazilian SARS-CoV-2 isolates.

PMID: 34740719 2022 Virus research

Table: V1176F

Isolation of SARS-CoV-2 B.1.1.28.2 (P2) variant and pathogenicity comparison with D614G variant in hamster model.

PMID: 34959053 2022 Journal of infection and public health

Result: The amino acid substitutions detected in both the isolates were D614G, E484K, V1176F in the spike, A119S, G204R, M234I, R203K in the N, L205V in NSP5, L71F in NSP7 and P32L in NSP 12.

Discussion: The characteristic spike mutations in P2 lineage are D614G, E484K and V1176F.

Molecular definition of severe acute respiratory syndrome coronavirus 2 receptor-binding domain mutations: Receptor affinity versus neutralization of receptor interaction.

PMID: 34240429 2022 Allergy

Table: V1176F

SARS-CoV-2 Mutations and Their Impact on Diagnostics, Therapeutics and Vaccines.

PMID: 35273977 2022 Frontiers in medicine

Table: V1176F

Evolutionary history of the SARS-CoV-2 Gamma variant of concern (P.1): a perfect storm.

PMID: 35266951 2022 Genetics and molecular biology

Introduction: Currently, the WHO has identified the Gamma lineage (B.1.1.28.1, P.1 or Gamma; Nextstrain clade 20J/V3) with the following key S mutations: L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, D614G, H655Y, T1027I, and V1176F.

A screening strategy for identifying the dominant variant of SARS-COV-2 in the fifth peak of Kurdistan- Iran population using HRM and Probe-based RT-PCR assay.

PMID: 35271889 2022 Journal of virological methods

Table: V1176F

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