literature

SARS_CoV_2 mutation literature information.

B.1.526 SARS-CoV-2 Variants Identified in New York City are Neutralized by Vaccine-Elicited and Therapeutic Monoclonal Antibodies.

PMID: 34311587 2021 mBio

Introduction: The B.1.526 variant spike proteins contain the D614G mutation, a shared set of novel mutations (L5F, T95I, D253G, and A701V), and either E484K or S477N, both of which lie within the RBD.

Introduction: Two versions of B.1.526 were identified, both having the D614G and A701V mutations and, in addition, the mutations L5F, T95I, and D253G, which are not present in previously reported variants.

Mutational analysis in international isolates and drug repurposing against SARS-CoV-2 spike protein: molecular docking and simulation approach.

PMID: 34307771 2021 Virusdisease

Table: T95I

Trajectory of Growth of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Variants in Houston, Texas, January through May 2021, Based on 12,476 Genome Sequences.

PMID: 34303698 2021 The American journal of pathology

Result: Eighteen patients with this N440K replacement were identified, and 10 patients had the identical combination of spike amino acid replacements: L18R, T95I, R158S, N440K, D614G, P681H, A688V, S735A, and T1027I.

Evolutionary Tracking of SARS-CoV-2 Genetic Variants Highlights an Intricate Balance of Stabilizing and Destabilizing Mutations.

PMID: 34281387 2021 mBio

Table: T95I

Emerging mutation in SARS-CoV-2 spike: Widening distribution over time in different geographic areas.

PMID: 34271250 2021 Biomedical journal

Table: T95I

Discussion: We found 17 mutation types of total sequences located within the NTD including T22I, P25L, T29I, Y38C, H49Y, S50L, F86S, T95I, E96G, S151G, N185K, N188K, V213L, S221W, S247R, G261D and Y279N.

Temporal landscape of mutational frequencies in SARS-CoV-2 genomes of Bangladesh: possible implications from the ongoing outbreak in Bangladesh.

PMID: 34251592 2021 Virus genes

Result: In our analysis, more than 20 nonsynonymous mutation sites were identified in the S protein, in which 13 (S13I, Q14H, P26L, H49Y, G75V, T75I, S95F, T95I, V127F, D138H, N211Y, Y248H, and S255F) were observed in the N-terminal domain (NTD).

Rapid Increase of SARS-CoV-2 Variant B.1.1.7 Detected in Sewage Samples from England between October 2020 and January 2021.

PMID: 34128696 2021 mSystems

Table: T95I

Characterization of the emerging B.1.621 variant of interest of SARS-CoV-2.

PMID: 34403832 2021 Infection, genetics and evolution

Result: However, a distinctive profile of synonymous and non-synonymous substitutions was found in the Spike protein of B.1.621, including T95I, Y144T, Y145S in the N-terminal domain in addition to substitutions R346K, E484K and N501Y in the RBD, P681H in the S1/S2 furin cleavage site (Table 1 ) and the insertion 146N in the N-terminal domain (NTD) (supplementary table 1).

The Spike of Concern-The Novel Variants of SARS-CoV-2.

PMID: 34071984 2021 Viruses

Introduction: Although the B.1.526 NTD harbours with L5F, T95I, and D253G, three mutations which are distinct from B.1.429, the 3D model of B.1.526 spike predicts a similar structural rearrangement of loop N5 (245-264aa) (Figure 6d).

Introduction: There are seven additional mutations (T19R, K77T, T95I, E154K, N440K, T478K, H1101D) that occur with varying frequencies in the B.1.617 sequence background.

An Epidemiological Analysis of SARS-CoV-2 Genomic Sequences from Different Regions of India.

PMID: 34067745 2021 Viruses

Discussion: In addition, this study observed the presence of individual amino acid variants in the SARS-CoV-2 variants B.1.1.7 (S494P), B.1.525 (A67V, Q677H), B.1.526 (L5F, T95I, S477N), and P2 (V1176F) in the earlier samples.

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