ViMRT
}  
 
Home   
< Docs   

 SARS_CoV_2 mutation literature information.


  Mutation-Induced Long-Range Allosteric Interactions in the Spike Protein Determine the Infectivity of SARS-CoV-2 Emerging Variants.
 PMID: 34805715       2021       ACS omega
Table: T95I


  A rigorous framework for detecting SARS-CoV-2 spike protein mutational ensemble from genomic and structural features.
 PMID: 34806033       2021       Current research in structural biology
Introduction: The lineage B.1.526 is classified as a Variant of Interest (VOI) which have multiple spike mutations with unique substitutions L5F, T95I, and, D253G, which were not present earlier in any other lineages.
Result: For the characteristic NTD mutations across VoCs (L18F, T19R, T20N, D80A, and T95I), we observed the MTR score of0.738 suggesting that these mutations show a neutral impact on the protein structure.


  SARS-CoV-2 variant with mutations in N gene affecting detection by widely used PCR primers.
 PMID: 34698407       2021       Journal of medical virology
Result: hCoV-19/Finland/FinD796H/2021 had a very uncommon combination of the S protein mutations, as only 0,04% (535/1204022) of complete genome sequences deposited to Gisaid at 23.4.2021 had a similar combination (S:T95I, S: 144del, S:E484K, S:D614G, S:P681H, and S:D796D&H).


  Evidence for retained spike-binding and neutralizing activity against emerging SARS-CoV-2 variants in serum of COVID-19 mRNA vaccine recipients.
 PMID: 34688034       2021       EBioMedicine
Discussion: The least negative impact on neutralization was seen for Iota variant, which is reasonable since this isolate has very few changes in the spike protein (T95I, D253G and D614G) compared to the wild type WA1 isolate.


  Spike protein evolution in the SARS-CoV-2 Delta variant of concern: a case series from Northern Lombardy.
 PMID: 34651569       2021       Emerging microbes & infections
Discussion: K77T and T95I (typical of B.1.617 v.1), L216F, A222V, and G1124V have also been rarely reported.
Discussion: AY.3.1 never harbours T95I nor A222V, and harbours F157C and R158G at about 10% frequencies.


  Evaluation of the clinical and analytical performance of the Seegene allplex SARS-CoV-2 variants I assay for the detection of variants of concern (VOC) and variants of interests (VOI).
 PMID: 34628158       2021       Journal of clinical virology
Table: T95I


  Development of an efficient Sanger sequencing-based assay for detecting SARS-CoV-2 spike mutations.
 PMID: 34905589       2021       PloS one
Abstract: Here, we developed five SARS-CoV-2 spike gene primer pairs (5-SSG primer assay; 69S, 144S, 417S, 484S, and 570S) and verified their ability to detect nine key spike mutations (DeltaH69/V70, T95I, G142D, DeltaY144, K417T/N, L452R, E484K/Q, N501Y, and H655Y) using a Sanger sequencing-based assay.


  Serum Neutralizing Activity of mRNA-1273 against SARS-CoV-2 Variants.
 PMID: 34549975       2021       Journal of virology
Table: T95I


  SARS-CoV-2 Delta (B.1.617.2) Variant: A Unique T478K Mutation in Receptor Binding Motif (RBM) of Spike Gene.
 PMID: 34796036       2021       Immune network
Table: T95I


  Booster of mRNA-1273 Strengthens SARS-CoV-2 Omicron Neutralization.
 PMID: 34931200       2021       medRxiv
Introduction: The Omicron spike in this study contained mutations A67V, Delta69-70, T95I, G142D, Delta143-145, Delta211, L212I, +214EPE, G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H, T547K,



Browser Board

 Co-occurred Entities




   Filtrator