literature

Monoclonal antibodies targeting two immunodominant epitopes on the Spike protein neutralize emerging SARS-CoV-2 variants of concern.

PMID: 35078012 2022 EBioMedicine

Result: We have performed a test of binding of chimeric antibodies AX677ch and AX290ch to the ectodomain trimer of the Omicron S protein (carrying mutations A67V, HV69-70del, T95I, G142D, VYY143-145del, N211del, L212I, ins214EPE, G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R,

PMID: 35062348 2022 Viruses

Introduction: The Spike of Mu accumulated the following mutations: insertion in 146N, T95I, Y144T and Y145S, in the N-terminal domain (NTD); R346K, E484K, N501Y in the receptor-binding domain (RBD) and P681H at the S1/S2 interface.

Discriminatory Weight of SNPs in Spike SARS-CoV-2 Variants: A Technically Rapid, Unambiguous, and Bioinformatically Validated Laboratory Approach.

PMID: 35062327 2022 Viruses

Introduction: The Iota variant has six mutations on the spike gene (L5F, T95I, D253G, E484K, D614G, and A701V), whilst the Lambda variant is characterized by seven mutations on the same gene (G75V, T76I, del246/252, L452Q, F490S, D614G, and T859N).

Omicron escapes the majority of existing SARS-CoV-2 neutralizing antibodies.

PMID: 35016194 2022 Nature

Method: Omicron pseudovirus contains the following mutations: A67V, H69del, V70del, T95I, G142D, V143del, Y144del, Y145del, N211del, L212I, ins214EPE, G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R,

PMID: 34906769 2022 Biomedicine & pharmacotherapy

Table: T95I

Emergence of a novel SARS-CoV-2 Pango lineage B.1.1.526 in West Bengal, India.

PMID: 34896696 2022 Journal of infection and public health

Introduction: It has three sublineages B.1.617.1/Kappa (S protein mutations: T95I, G142D, E154K, L452R, E484Q, D614G, P681R and Q1071H), B.1.617.2/Delta (S protein mutations: T19R, E156G, Delta157-158, L452R, T478K, D614G, P681R, D950N), and B.1.617.3 (S glycoprotein mutations: T19R, G142D,

PMID: 34896524 2022 Gene

Table: T95I

The significant immune escape of pseudotyped SARS-CoV-2 variant Omicron.

PMID: 34890524 2022 Emerging microbes & infections

Result: There are 32 mutations on the Spike of Omicron, including the following sites: A67V, H69del-V70del, T95I, G142D-V143del-Y144del-Y145del, N211del-L212I, ins214EPE, G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H,

PMID: 34842496 2022 Emerging microbes & infections

Discussion: Apart from the lineage-defining changes in variants Delta-like, additional substitutions were observed such as T95I, P251L in the N-terminal domain, Q613H and T719I during the following weeks (data not shown).

Longitudinal analysis of SARS-CoV-2 spike and RNA-dependent RNA polymerase protein sequences reveals the emergence and geographic distribution of diverse mutations.

PMID: 34801754 2022 Infection, genetics and evolution

Result: first detected in New York (L5F, T95I, D253G; E484K or S477N; D614G, and A701V), appear together consistently after the week of October 4th, 2020, though the fact that many of these mutations are shared with other phylogenetic lineages makes it difficult to conclude that the variant originated at this time point.