Introduction: The Spike of Mu accumulated the following mutations: insertion in 146N, T95I, Y144T and Y145S, in the N-terminal domain (NTD); R346K, E484K, N501Y in the receptor-binding domain (RBD) and P681H at the S1/S2 interface.
Discriminatory Weight of SNPs in Spike SARS-CoV-2 Variants: A Technically Rapid, Unambiguous, and Bioinformatically Validated Laboratory Approach.
Introduction: The Iota variant has six mutations on the spike gene (L5F, T95I, D253G, E484K, D614G, and A701V), whilst the Lambda variant is characterized by seven mutations on the same gene (G75V, T76I, del246/252, L452Q, F490S, D614G, and T859N).
Omicron escapes the majority of existing SARS-CoV-2 neutralizing antibodies.
Emergence of a novel SARS-CoV-2 Pango lineage B.1.1.526 in West Bengal, India.
PMID: 34896696
2022
Journal of infection and public health
Introduction: It has three sublineages B.1.617.1/Kappa (S protein mutations: T95I, G142D, E154K, L452R, E484Q, D614G, P681R and Q1071H), B.1.617.2/Delta (S protein mutations: T19R, E156G, Delta157-158, L452R, T478K, D614G, P681R, D950N), and B.1.617.3 (S glycoprotein mutations: T19R, G142D, PMID: 34896524
2022
Gene
Table: T95I
The significant immune escape of pseudotyped SARS-CoV-2 variant Omicron.
Result: There are 32 mutations on the Spike of Omicron, including the following sites: A67V, H69del-V70del, T95I, G142D-V143del-Y144del-Y145del, N211del-L212I, ins214EPE, G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H, PMID: 34842496
2022
Emerging microbes & infections
Discussion: Apart from the lineage-defining changes in variants Delta-like, additional substitutions were observed such as T95I, P251L in the N-terminal domain, Q613H and T719I during the following weeks (data not shown).
Longitudinal analysis of SARS-CoV-2 spike and RNA-dependent RNA polymerase protein sequences reveals the emergence and geographic distribution of diverse mutations.
PMID: 34801754
2022
Infection, genetics and evolution
Result: first detected in New York (L5F, T95I, D253G; E484K or S477N; D614G, and A701V), appear together consistently after the week of October 4th, 2020, though the fact that many of these mutations are shared with other phylogenetic lineages makes it difficult to conclude that the variant originated at this time point.
SARS_CoV_2 mutation literature information.
PMID: 
2022
Frontiers in medicine
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