literature

SARS_CoV_2 mutation literature information.

Chimeric crRNA improves CRISPR-Cas12a specificity in the N501Y mutation detection of Alpha, Beta, Gamma, and Mu variants of SARS-CoV-2.

PMID: 34941928 2021 PloS one

Discussion: To further differentiate Alpha, Beta, Gamma, and Mu, other mutation sites in the Spike protein like 69-70 deletion or 144 deletion, 242-244 deletion or K417N, R190S or K417T, T95I or R346K can be detected respectively.

SARS-CoV-2 Delta Variant Displays Moderate Resistance to Neutralizing Antibodies and Spike Protein Properties of Higher Soluble ACE2 Sensitivity, Enhanced Cleavage and Fusogenic Activity.

PMID: 34960755 2021 Viruses

Introduction: B.1.617.1 contains additional substitutions in the NTD (T95I), the NTD antigenic supersite beta-hairpin (G142D and E154K), within the S1/S2 cleavage junction (P681R), and in the S2 subunit (Q1071H).

Prediction of SARS-CoV-2 Variant Lineages Using the S1-Encoding Region Sequence Obtained by PacBio Single-Molecule Real-Time Sequencing.

PMID: 34960813 2021 Viruses

Result: Taken together, the most frequently missed mutations were G142D (n = 11), E156G, 157del, 158del (n = 6), N501Y (n = 6), S477N (n = 5), T95I (n = 3), V130F (n = 2), and E484K (n = 2).

Result: The missing mutations were not located in the same region as previously, but rather over the amplicon NC_045512.2:21743-21961 (T95I, V130F, G142D, E156G, F157del, and R158del, A222V).

Bioinformatic analysis of the whole genome sequences of SARS-CoV-2 from Indonesia.

PMID: 34540148 2021 Iranian journal of microbiology

Table: T95I

Evolution, Mode of Transmission, and Mutational Landscape of Newly Emerging SARS-CoV-2 Variants.

PMID: 34465019 2021 mBio

Table: T95I

Community-level SARS-CoV-2 sequence diversity revealed by wastewater sampling.

PMID: 34438144 2021 The Science of the total environment

Table: T95I

Genome Sequencing Reveals a Mixed Picture of SARS-CoV-2 Variant of Concern Circulation in Eastern Uttar Pradesh, India.

PMID: 35071267 2021 Frontiers in medicine

Result: In the second wave of 38 cases, aa variation at T95I was detected in 71.4% cases (Delta = 12, Delta AY.1 = 6, and Kappa = 2).

Table: T95I

ACE2-targeting monoclonal antibody as potent and broad-spectrum coronavirus blocker.

PMID: 34433803 2021 Signal transduction and targeted therapy

Method: B.1.617.1: T95I, G142D, E154K, L452R, E484Q, D614G, P681R, Q1071H.

Emergence and expansion of SARS-CoV-2 B.1.526 after identification in New York.

PMID: 34428777 2021 Nature

Introduction: B.1.526-E484K and B.1.526-S477N share the characteristic spike protein mutations L5F, T95I, D253G, D614G and either A701V or Q957R, along with either E484K or S477N.

Introduction: Pseudoviruses were constructed containing S477N or E484K alone, or containing all five signature mutations (L5F, T95I, D253G, A701V and E484K or S

A persistently replicating SARS-CoV-2 variant derived from an asymptomatic individual.

PMID: 32967693 2020 Journal of translational medicine

Result: Alignment analyses showed that, with respect to the Wuhan-Hu-1 Reference Genome NC_045512.2, SARS-CoV-UNIBS-2 AP66 consensus sequence displayed 6 nucleotide substitutions (C241T; C3037T; C14408T; T21784G; C21846T; A23403G) leading to 4 non-synonymous changes (ORF1ab polypeptide: P4715L; S protein: N74K, T95I, D614G).

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