literature

SARS_CoV_2 mutation literature information.

Antigenicity of the Mu (B.1.621) and A.2.5 SARS-CoV-2 Spikes.

PMID: 35062348 2022 Viruses

Introduction: The Spike of Mu accumulated the following mutations: insertion in 146N, T95I, Y144T and Y145S, in the N-terminal domain (NTD); R346K, E484K, N501Y in the receptor-binding domain (RBD) and P681H at the S1/S2 interface.

Omicron variant (B.1.1.529) of SARS-CoV-2: understanding mutations in the genome, S-glycoprotein, and antibody-binding regions.

PMID: 35258772 2022 GeroScience

Abstract: New mutations were found in the NTD (Delta143-145, A67V, T95I, L212I, and Delta211) including one new mutation in fusion peptide (D796Y).

Result: Significant mutations in the RBD include Q493K, G496S, Q498R, S477N, G466S, N440K, and Y505H, whereas those in the NTD included Delta143-145, A67V, T95I, L212I, and Delta211.

Using genomic epidemiology of SARS-CoV-2 to support contact tracing and public health surveillance in rural Humboldt County, California.

PMID: 35255849 2022 BMC public health

Figure: *The parental B.1.311 lineage in this case gave rise to additional de novo mutations in Spike in some downstream members of this clade, including N501Y, and T95I.

Rapidly Identifying New Coronavirus Mutations of Potential Concern in the Omicron Variant Using an Unsupervised Learning Strategy.

PMID: 35233566 2022 Research square

Abstract: To build an investigative framework, we have applied an unsupervised machine learning approach to 4296 Omicron viral genomes collected and deposited to GISAID as of December 14, 2021, and have identified a core haplotype of 28 polymutants (A67V, T95I, G339D, R346K, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H,

Misidentification of the SARS-CoV-2 Mu variant using commercial mutation screening assays.

PMID: 35194675 2022 Archives of virology

Table: T95I

mRNA-1273 Vaccine-elicited Neutralization of SARS-CoV-2 Omicron in Adolescents and Children.

PMID: 35118475 2022 medRxiv

Method: The Omicron (B.1.1.529) variant contained spike mutations A67V, Delta69-70, T95I, G142D, Delta143-145, Delta211, L212I, +214EPE, G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H, T547K,

Divergent SARS-CoV-2 Omicron-reactive T and B cell responses in COVID-19 vaccine recipients.

PMID: 35113647 2022 Science immunology

Method: The omicron variant contained the following spike mutations: A67VS, del69-70, T95I, G142-, del143-144, Y145D, del211, L212I, ins215EPE, G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H, T547K, D614G,

Memory B cell repertoire from triple vaccinees against diverse SARS-CoV-2 variants.

PMID: 35090164 2022 Nature

Method: In additional to the reported mutations (A67V, Delta69-70, T95I, G142D, Delta143-145, Delta211, L212I, ins214EPE, G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H, T547K, D614G,

PMID: 35078012 2022 EBioMedicine

Result: We have performed a test of binding of chimeric antibodies AX677ch and AX290ch to the ectodomain trimer of the Omicron S protein (carrying mutations A67V, HV69-70del, T95I, G142D, VYY143-145del, N211del, L212I, ins214EPE, G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R,

PMID: 34842496 2022 Emerging microbes & infections

Discussion: Apart from the lineage-defining changes in variants Delta-like, additional substitutions were observed such as T95I, P251L in the N-terminal domain, Q613H and T719I during the following weeks (data not shown).

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