Abstract: On the other hand, during almost all months analyzed, OTU_5 characterized by the mutation T85I in nsp2 is the most frequent in North America.
Pan-India novel coronavirus SARS-CoV-2 genomics and global diversity analysis in spike protein.
Result: Other key variants including ORF3a: Q57H, ORF1ab: T265I (NSP3: T85I), ORF8: L84S, N203 (204del-insKR), ORF1ab: L3606F (NSP6, L37F) were also observed in genomes retrieved from India.
SARS-CoV-2 variants reveal features critical for replication in primary human cells.
Abstract: Notably, naturally occurring variants in Orf3a (Q57H) and nsp2 (T85I) were associated with poor replication in Vero-CCL81 cells but not in BEpCs, while SARS-CoV-2 isolates expressing the Spike D614G variant generally exhibited enhanced replication abilities in BEpCs.
Introduction: Notably, SARS-CoV-2 isolates with naturally occurring Orf3a (Q57H) and nsp2 (T85I) substitutions exhibited a cell-specific replication phenotype, with efficient propagation restricted to primary human BEpCs.
Result: Orf3a (Q57H) and n
Genome-wide analysis of 10664 SARS-CoV-2 genomes to identify virus strains in 73 countries based on single nucleotide polymorphism.
Abstract: As a consequence, T85I, Q57H and R203M in NSP2, ORF3a and Nucleocapsid respectively are found to be responsible for Cluster 1 as they are damaging and unstable non-synonymous signature SNPs.
Table: T85I
Discussion: From the consensus of both PROVEAN and PolyPhen-2, it can be seen from Table 6 that out of 16 unique non-synonymous signature SNPs, 5 are predicted to be deleterious or damaging, out of which T85I, Q57H and R203M are in NSP2, ORF3a and Nucleocapsid respectively for Cluster 1.
Impact of meteorological parameters and population density on variants of SARS-CoV-2 and outcome of COVID-19 pandemic in Japan.
Result: Among 22 point mutations at N and other eight non-structural proteins, eight namely, N_S194L, N_R203K, N_G204R, NS3_Q57H, NSP2_T85I, NSP5_G15S, NSP6_L37F and NSP12_P323L were persistent throughout the COVID-19 pandemic in Japan.
Table: T85I
The Novel Coronavirus Enigma: Phylogeny and Analyses of Coevolving Mutations Among the SARS-CoV-2 Viruses Circulating in India.
PMID: 33496683
2020
JMIR bioinformatics and biotechnology
Result: We also observed 1059T>A (T85I) change within the NSP2 gene (n=2) and 6466A>G (K1249K) change in the NSP3 gene (n=2).
Discussion: Few infrequent mutations at position 1059 T>A (T85I) in NSP2 and 8782 C>T (S76S) in NSP4 observed here have also been reported to be prevalent in other countries.
Potentially adaptive SARS-CoV-2 mutations discovered with novel spatiotemporal and explainable AI models.
Result: 2) consists of the mutation Thr85Ile at the same loop of nsp2, followed by Gln57His in ORF3a; site 57 is predicted to be part of a helix break at the first transmembrane segment.
Result: The fifth branch (12-13) is defined by the Thr85Ile mutation in nsp2 followed by Gln57His in ORF3a.
Variant analysis of SARS-CoV-2 genomes.
PMID: 32742035
2020
Bulletin of the World Health Organization
Result: Other variants including ORF3a Q57H (2893 samples), ORF1ab T265I (NSP3 T85I; 2442 samples), ORF8 L84S (1669 samples), N203_204delinsKR (1573 samples), ORF1ab L3606F (NSP6 L37F; 1070 samples) were the key variants for identifying clades.
SARS_CoV_2 mutation literature information.
PMID: 
2021
Reviews in medical virology
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