Result: Of the 93 substitutions that were present in 2020, 61 were no longer present during March 2021 (Figure 5C), and only 8 were present in >5% of samples during March 2021 (NSP2:T85I, NSP12:P323L, S:L5F, S:D614G, NS3aQ57H, NS8:S24L, N:R203K, and N:G204R).
Result: The most common amino acid substitutions across lineages were S:D614G, NSP12:P323L, NSP2:
Identification of genotypic variants and its proteomic mutations of Brazilian SARS-CoV-2 isolates.
Discussion: This included T85I in the nsp2 gene, P423L in the nsp12 gene, D614G in the S gene, and Q57H in the ORF3a gene.
Global variation in SARS-CoV-2 proteome and its implication in pre-lockdown emergence and dissemination of 5 dominant SARS-CoV-2 clades.
PMID: 34147651
2021
Infection, genetics and evolution
Abstract: Among the 7 highly recurring (percentage frequency>=10%) mutations (Nsp2:T85I, Nsp6:L37F, Nsp12:P323L, Spike:D614G, ORF3a:Q57H, N protein:R203K and N protein:G204R), N protein:R203K and N protein: G204R are co-occurring (dependent) mutations.
Abstract: Further, the occurrence of ORF3a: PMID: 34428777
2021
Nature
Introduction: Non-spike mutations widely shared by B.1.526-E484K and B.1.526-S477N isolates include: T85I in ORF1a-nsp2; L438P in ORF1a-nsp4, a 9-base pair (bp) deletion (Delta106-108) in ORF1a-nsp6; P323L in ORF1b-nsp12; Q88H in ORF1b-nsp13; Q57H in ORF3a; and P199L and M234I in the N<
Correlates of SARS-CoV-2 Variants on Deaths, Case Incidence and Case Fatality Ratio among the Continents for the Period of 1 December 2020 to 15 March 2021.