Longitudinal analysis of SARS-CoV-2 spike and RNA-dependent RNA polymerase protein sequences reveals the emergence and geographic distribution of diverse mutations.
PMID: 34801754
2022
Infection, genetics and evolution
Figure: Mutations associated with the Alpha variant of concern (H69_V70del, Y145del, N501Y, A570D, D614G, P681H, T716I, S982A, and D1118H) have rapidly increased in prevalence since the appearance of the variant in mid-September 2020.
Figure: Some mutations associated with the Beta variant of concern (H69_V70del, Y145del, N501Y, D614G, P681H, and T716I) were present separately before the emergence of the variant in mid-September 2020, while others (A570D, S982A
Assessment of the binding interactions of SARS-CoV-2 spike glycoprotein variants.
PMID: 34545316
2022
Journal of pharmaceutical analysis
Introduction: This variant is defined as lineage B.1.1.7 and has multiple spike protein amino acid deletions and mutations, such as deletion 69-70, deletion 144, and mutations N501Y, A570D, D614G, P681H, T716I, S982A, and D1118H.
An Update on Severe Acute Respiratory Syndrome Coronavirus 2 Diversity in the US National Capital Region: Evolution of Novel and Variants of Concern.
Result: Filtering for more common substitutions (Supplementary Figure 1B) showed a major increase in February in changes associated with B.1.1.7 (eg, S:N501Y, S:A570D, S:T716I, S:S982A, and S:D1118H) while substitutions associated with B.1.2 declined.
Molecular definition of severe acute respiratory syndrome coronavirus 2 receptor-binding domain mutations: Receptor affinity versus neutralization of receptor interaction.
Abstract: Twenty-two distinct mutations were identified within the spike protein regions which were: L5F, L18F, T19R, S151T, G181A, A222V, A348S, L452 (Q or M), T478K, N501Y, A520S, A522V, A570D, S605A, D614G, Q675H, N679K, P681H, T716I, S982A, A1020S, PMID: 34848355
2022
Infection, genetics and evolution
Abstract: In addition, the profiling of sub-haplotypes indicated that sub-haplotype 2A_1 with the mutations at N501Y, A570D, D614G, P681H, T716I, S982A, and D118H in Spike was over 58% in May 2021 in the high partly vaccinated rate group (US, Canada, and Germany).
Result: Among the sub-haplotypes of haplotype 2A variants, sub-haplotype 2A_1 was the most prevalent sub-haplotype in the partly vaccinated rate group, containing three mutations in nsp3 (T183I, A890D, I1412T), seven new mutations in Spike protein ( PMID: 34896696
2022
Journal of infection and public health
Introduction: Along with the clade specific mutations, these variants have their own sets of characteristics mutations including several mutations in the S glycoprotein like Delta69-70, Delta144-145, N501Y, A570D, P681H, T716I, S982A, D1118H in the Alpha variant; D80A, D215G, Delta241-243, K417N, E484K, N501Y, A701V in the Beta variant; L18F, T20N, P26S, D138Y, R190S,
A comprehensive overview of identified mutations in SARS CoV-2 spike glycoprotein among Iranian patients.
Discussion: Also, there were two other sequences sampled from Shiraz in January 2021, which had five specific mutations as indicator of the Alpha variant (D614G, H69del, N501Y, V70del, Y144del) and were clustered along with the Alpha variants in phylogenetic tree; however, these sequences did not contain the other specific mutations of Alpha variant including A570D, D1118H, L699I, P681H, S982A and T716I.
Antigenicity comparison of SARS-CoV-2 Omicron sublineages with other variants contained multiple mutations in RBD.
A year living with SARS-CoV-2: an epidemiological overview of viral lineage circulation by whole-genome sequencing in Barcelona city (Catalonia, Spain).
Result: The D614G (96.4%) substitution was observed in most viral genomes, in addition to multiple mutations defining lineages, such as the mutation set Delta69-70, Delta144, N501Y, A570D, P681H, T716I, S982A, and D1118H for B.1.1.7 viruses.
SARS_CoV_2 mutation literature information.
PMID: 
2022
Infection, genetics and evolution
Browser Board
Co-occurred Entities
Filtrator
ViMRT