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 SARS_CoV_2 mutation literature information.


  ACE2-targeting monoclonal antibody as potent and broad-spectrum coronavirus blocker.
 PMID: 34433803       2021       Signal transduction and targeted therapy
Method: B.1.1.7: H69 deletion, V70 deletion, Y144deletion, N501Y, A570D, D614G, P681H, T716I, S982A, D1118H.


  Molecular Epidemiology of SARS-CoV-2 in Diverse Environmental Samples Globally.
 PMID: 34442775       2021       Microorganisms
Abstract: However, the key mutations-N501Y (44.6%), S982A (44.4%), A570D (43.3%), T716I (40.4%), and P681H (40.1%) were also recorded in spike protein.
Result: The most common amino acid substitutions were D614G (83.4%) followed by N501Y (44.6%), S982A (44.4%), A570D (43.3%), T716I (40.4%), and P681H (40.1%) in Spike (S) protein.


  Novel Nested-Seq Approach for SARS-CoV-2 Real-Time Epidemiology and In-Depth Mutational Profiling in Wastewater.
 PMID: 34445204       2021       International journal of molecular sciences
Result: According to the % frequencies of the genetic markers A570D (23271C>A), D614G (23403A>G), P681H (23604C>A), T716I (23709C>T), S982A (24506T>G), and D1118H (24914GG>C), the Beta.1.1.7/alpha lineage VOC was detected in 80.6% +- 8.3 (mean +- SE), (median of 80.8%) of the total sequencing reads.


  Rise and Fall of SARS-CoV-2 Lineage A.27 in Germany.
 PMID: 34452356       2021       Viruses
Result: Intriguingly, one of the genomes (EPI_ISL_1567985) encoded S-L452R, S-N501Y, and S-G1219V associated with six other amino acid changes in the spike (A570D, D614G, P681H, T716I, S982A, I1221V), most interestingly comprising D614G and also P681H (Figure 4B).


  Monitoring SARS-CoV-2 Populations in Wastewater by Amplicon Sequencing and Using the Novel Program SAM Refiner.
 PMID: 34452511       2021       Viruses
Result: Sequences from the S1S2 amplicon matched lineage B.1.1.7 with '1841G(D614G) 2042A(P681H) 2147T(T716I)', lineage P.1 with '1841G(D614G) 1963T(H655Y) 2063T(A688V)' or the B.1 lineage with only the now ubiquitous D614G variation (Supplementary 12).


  Evolution, Mode of Transmission, and Mutational Landscape of Newly Emerging SARS-CoV-2 Variants.
 PMID: 34465019       2021       mBio
Table: T716I


  Phylogenicity of B.1.1.7 surface glycoprotein, novel distance function and first report of V90T missense mutation in SARS-CoV-2 surface glycoprotein.
 PMID: 34466389       2021       Meta gene
Method: 3 to B.1.1.7 spike protein defining mutations - defining deletions:H69,V70,Y144/ Y145 plus defining amino acid substitutions: N501Y, A570D, D614G, P681H, T716I, S982A, D1118H, two types of events can be observed in 21 out of 24 variants: .
Method: 3 to B.1.1.7 spike protein defining mutations - defining deletions:H69,V70,Y144/ Y145 plus defining amino acid substitutions: N501Y, A570D, D614G,
Discussion: On the other hand, variant V20 profiles most deletions of defining amino acid substitutions: A570D, D614G and T716I.


  Crucial Mutations of Spike Protein on SARS-CoV-2 Evolved to Variant Strains Escaping Neutralization of Convalescent Plasmas and RBD-Specific Monoclonal Antibodies.
 PMID: 34484190       2021       Frontiers in immunology
Introduction: In addition, several recent studies have focused on the neutralizing activity of vaccine-elicited humoral immunity against new circulating mutant lineages, including B.1.1.7 (United Kingdom, bearing mutations 69-70 del, 144 del, N501Y, A570D, D614G, P681H, T716I, S982A, and D1118H in the spike protein), B.1.429 (United States, bearing mutations S13I, W152C, L452R, and D614G in the spike protein), B.1.351(South Africa, bearing mutations D80A, D215G,  PMID: 34495709       2021       Journal of clinical microbiology
Introduction: The B.1.575.1 sublineage was classified in the Phylogenetic Assignment of Named Global Outbreak (PANGO) lineage system as a Spanish sublineage of B.1.575 with spike mutations P681H, S494P, and T716I, and the B.1.575.2 sublineage, whose main characteristic is the presence of the E484K spike mutation, also originated in Spain.
Result: Among the common substitutions present in these lineages, four occurred in the spike protein (S494P, D614G, P681H, and T716I).


  AutoVEM2: A flexible automated tool to analyze candidate key mutations and epidemic trends for virus.
 PMID: 34512928       2021       Computational and structural biotechnology journal
Result: Among the 17 sites, 11 caused amino acid changes, of which 5 mutation sites were located on the S protein (including N501Y, P681H, T716I, S982A, and D1118H) (Table 3).
Table: 716T>I



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