Introduction: Eight of these mutations are in the spike protein (S), including 69/70/144 deletion, N501Y, A570D, P681H, T716I, S982A, D1118H.
Table: T716I
Omicron N501Y mutation among SARS-CoV-2 lineages: Insilico analysis of potent binding to tyrosine kinase and hypothetical repurposed medicine.
PMID: 34929375
2022
Travel medicine and infectious disease
Result: The tested mutations include spike mutants of T716I, N501Y, A570D, P681H, D1118H, 982A, deletion 69-70, deletion 145, with lineage B.1.1.7 variant spike.
Pierce into Structural Changes of Interactions Between Mutated Spike Glycoproteins and ACE2 to Evaluate Its Potential Biological and Therapeutic Consequences.
PMID: 34931119
2022
International journal of peptide research and therapeutics
Result: According to the results of the multiple sequence alignment, the mutations of the EPI_ISL_601443 variant were as follows: H69 deletion, V70 deletion, Y144 deletion, N501Y substitution, A570D substitution, D614G substitution, P681H substitution, T716I substitution, S982A substitution, and D1118H substitution.
Enhanced fitness of SARS-CoV-2 variant of concern Alpha but not Beta.
Discussion: We have shown that the molecular mechanism underlying the fitness advantage of Alpha in vivo is largely dependent on a few changes in S, including three amino acid deletions (H69, V70 and Y144) and six substitutions (N501Y, A570D, P681H, T716I, S982A and D1118H).
Genomic characterization unravelling the causative role of SARS-CoV-2 Delta variant of lineage B.1.617.2 in 2nd wave of COVID-19 pandemic in Chhattisgarh, India.
Result: Mutations of P681 R/H, D950 N, T716I, S982A, Q1071H, and D1118H were located in proximity to the S1/S2 cleavage site.
Result: Three (3.6%) sequences belonged to the Alpha variant (lineage B.1.1.7/clade GR/501Y.V1) and showed a mutational pattern of N501Y, A570D, D614G, P681H, T716I, S982A, D1118H, and three deletions of H69, V70, and Y144.
Discussion: Alpha variant B.1.1.7 was found in one case each from vaccine breakthrough, mild and dead patient category showing nonsynonymous muta
Infectivity and antigenicity of pseudoviruses with high-frequency mutations of SARS-CoV-2 identified in Portugal.
Result: Compared to the Wuhan-Hu-1 variant, VOC Alpha is characterized by the occurrence of 9 genetic markers in the S gene (69-70del, 144del, N501Y, A570D, D614G, P681H, T716I, S928A and D11
Result: The relative abundance of each marker from most to least abundant was D614G > A570D > 69-70del and 144del > D1118H > S982A > P681H and T716I > N501Y > E584K (Table 2).
Emergence of a novel SARS-CoV-2 Pango lineage B.1.1.526 in West Bengal, India.
PMID: 34896696
2022
Journal of infection and public health
Introduction: Along with the clade specific mutations, these variants have their own sets of characteristics mutations including several mutations in the S glycoprotein like Delta69-70, Delta144-145, N501Y, A570D, P681H, T716I, S982A, D1118H in the Alpha variant; D80A, D215G, Delta241-243, K417N, E484K, N501Y, A701V in the Beta variant; L18F, T20N, P26S, D138Y, R190S,
Discriminatory Weight of SNPs in Spike SARS-CoV-2 Variants: A Technically Rapid, Unambiguous, and Bioinformatically Validated Laboratory Approach.
Introduction: Announced in December 2020 and probably emerging in November 2020, the Alpha variant, the most commonly isolated variant worldwide, is characterized by the presence of the N501Y, A570D, P681H, T716I, S982A, and D1118H substitutions and deletions at positions 69/70 and 144 in the S gene.
Result: According to these observations, the subset including SNPs from R158G to T716I, sizing 1603 bp, would have been an excellent target for the test.
SARS_CoV_2 mutation literature information.
PMID: 
2022
PloS one
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