Introduction: However, there have been several mutations reported in SARS-CoV-2 RBD, such as N501Y, L452R, S477N, E484K, A502S, N439K, S494P, T478K, K417N, and K417T.
Expansion of L452R-Positive SARS-CoV-2 Omicron Variant, Northern Lombardy, Italy.
Discussion: In this study, we observed a reduced sensitivity of variants carrying L452R towards convalescent and vaccine-elicited sera that was further diminished by substitutions at E484 and T478K in S, respectively (Figure 1).
Discussion: This was in agreement with another recent study demonstrating a >10-fold resistance of Delta towards imdevimab and further receptor binding motif (RBM) binding antibodies suggesting that both the L452R and T478K substitutions reduce the neutralizing activity.
Linked nosocomial COVID-19 outbreak in three facilities for people with intellectual and developmental disabilities due to SARS-CoV-2 variant B.1.1.519 with spike mutation T478K in the Netherlands.
Discussion: Most likely, T478K could affect imdevimab neutralizing capacity, however, more studies are needed to evaluate the impact of T478K on S secondary structure and antibody binding.
Discussion: Specifically, using convalescent but not vaccine-elicited sera Kappa was neutralized 1.5-fold less effective than the T478K-carrying Delta variant.
Discussion: The T478K substitution appears more relevant for neutralization by convalescent sera.
Discussion: The reduced imdevimab susceptibility towards Delta compared to Kappa indicates that T478K, possibly in combination with other mutations found in Delta S, might mediate the observed immune escape.
Clinical Characterization and Genomic Analysis of Samples from COVID-19 Breakthrough Infections during the Second Wave among the Various States of India.
Result: Common in B.1.617.2 lineage: ORF1ab P4715L; spikeT19R, L452R, T478K, D614G, and P681R; ORF3a S26L; M I82T; ORF7a V82A and T120I; and N D63G, R203M, and D377Y.
Expansion of L452R-Positive SARS-CoV-2 Omicron Variant, Northern Lombardy, Italy.
PMID: 34602531
2021
The Journal of toxicological sciences
Abstract: In this assay, we determined L452R and T478K, among which T478K is an identifier of the Delta variant since L452R is seen in other strains (Kappa and Epsilon variants).
Abstract: Seven clinical samples containing the Delta variant were successfully identified as L452R/T478K mutants.
Linked nosocomial COVID-19 outbreak in three facilities for people with intellectual and developmental disabilities due to SARS-CoV-2 variant B.1.1.519 with spike mutation T478K in the Netherlands.
PMID: 34602531
2021
The Journal of toxicological sciences
Abstract: In addition, HRM analysis distinguished the T478K mutant from the wild-type T478.
Evaluation of the clinical and analytical performance of the Seegene allplex SARS-CoV-2 variants I assay for the detection of variants of concern (VOC) and variants of interests (VOI).
Figure: (a) Binding responses of anti-SARS-CoV-2 S protein mAbs, S1D2-hIgG1, STI-1499-LALA and 1741-LALA to the S1 fragment of the S protein from SARS-CoV-2 variants, including 2019-nCoV, B.1.1.7 (HV69-70 deletion, Y144 deletion, N501Y, A570D, D614G, P681H)-, B.1.351 (K417N, E484K, N501Y, D614G)-, and B.1.617.2 (T19R, G142D, E156G, 157-158 deletion, L452R, T478K, D614G, P681R)- lineage.
SARS-CoV-2 Virus-Host Interaction: Currently Available Structures and Implications of Variant Emergence on Infectivity and Immune Response.
PMID: 34639178
2021
International journal of molecular sciences
Discussion: Regarding infectivity, this strain possesses mutation D614G and one mutation in the RBD, T478K.
SARS_CoV_2 mutation literature information.
PMID: 
2021
Journal of virology
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