literature

SARS_CoV_2 mutation literature information.

SARS-CoV-2 Omicron neutralization by therapeutic antibodies, convalescent sera, and post-mRNA vaccine booster.

PMID: 34981057 2021 bioRxiv

Introduction: The predominant strain of Omicron has mutations in the spike gene encoding 15 amino acid changes in the receptor binding domain (RBD) of the spike surface protein (G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, and Y505H).

Differences in Clinical Characteristics Between Delta Variant and Wild-Type SARS-CoV-2 Infected Patients.

PMID: 35047533 2021 Frontiers in medicine

Discussion: T478K mutation enhanced the infectivity and augmented the ability of SARS-CoV-2 to escape immune recognition.

Discussion: Compared to other SARS-CoV-2 strains, the delta variant possesses notable mutations L452R, T478K, and E484Q in the RBD of S protein and P681R in the S1/S2 site.

RBD Double Mutations of SARS-CoV-2 Strains Increase Transmissibility through Enhanced Interaction between RBD and ACE2 Receptor.

PMID: 35062205 2021 Viruses

Result: L452R/E484Q was the most significant among the three RBD double mutants, followed by E484K/N501Y and L452R/T478K.

Result: L452R/ Result: However, the top five residues in each RBD double mutant were mostly changed from the wild-type RBD and their corresponding single mutations: L452/T478K changed to Y505, F486, N501, Q493, and T500; L452R/E484Q to F486, Q493, Y505, Y489, and F456; and E484K/N501Y to Y501, Y505, Q493, T500, and F486.

Tracking SARS-CoV-2 Spike Protein Mutations in the United States (January 2020-March 2021) Using a Statistical Learning Strategy.

PMID: 35062214 2021 Viruses

Result: It is natural to name the haplotype T478K-D614G-P681H-T732A as a B.1.1.222.

Genome Sequencing Reveals a Mixed Picture of SARS-CoV-2 Variant of Concern Circulation in Eastern Uttar Pradesh, India.

PMID: 35071267 2021 Frontiers in medicine

Abstract: Signature substitution at positions S:L452R, S:P681R, and S:D614G were commonly detected in the Delta, Delta AY.1, and Kappa variants whereas S:T19R and S:T478K were confined to Delta and Delta AY.1 variants only.

Result: Signature substitutions at positions L452R and P681R were commonly detected in the Delta, Delta AY.1, and Kappa variant whereas T19R, T478K, and D614G were confined to Delta and Delta AY.1 variant only.

Result: We also identified 8 subs

Omicron: A Heavily Mutated SARS-CoV-2 Variant Exhibits Stronger Binding to ACE2 and Potently Escapes Approved COVID-19 Therapeutic Antibodies.

PMID: 35140714 2021 Frontiers in immunology

Abstract: Notably, three substitutions, i.e., T478K, Q493K, and Q498R, significantly contribute to the binding energies and almost doubled the electrostatic potential (ELE) of the RBDOmic-ACE2 complex.

Abstract: Together, T478K, Q493K, Q498R, and E484A substitutions contribute to a significant drop in the ELE between RBDOmic-mAbs, particularly in etesevimab, bamlanivimab, and CT-p59.

Result: However, by performing endpoint molecular mechanics generalized born surface area (MMGBSA) binding free energy calculation, we could demonstrate a substantial increase in the binding affinity by T478K, Q493K, and Q498R, leading to an overall incr

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