Result: When incorporating D614G in monomutants, we were intrigued to find that mutation of T478I + D614G or E484K + D614G resulted in mutants with protein structure like the S-D614G mutant, while other amino acid changes at the same residues, such as T478R/K + D614G or E484Q + D614G,
Discussion: Amino acid change of T478I (polar to nonpolar residue) and E484K (negative- to positive-charge residue) did not contribute to the major shift of the S-D614G structure.
Postvaccination SARS-COV-2 among Health Care Workers in New Jersey: A Genomic Epidemiological Study.
Result: L452R, T478K/I, E484K/Q, and S494P mutations were identified in 32, 8, 40, and 29 genomes, respectively.
Phylogenomics and population genomics of SARS-CoV-2 in Mexico during the pre-vaccination stage reveals variants of interest B.1.1.28.4 and B.1.1.222 or B.1.1.519 and the nucleocapsid mutation S194L associated with symptoms.
Result: It is also interesting to note that mutations T478I/R, previously identified as dangerous, could not be found in Mexico during the period of analysis.
The Impact of Mutations in SARS-CoV-2 Spike on Viral Infectivity and Antigenicity.
Result: These variants include single amino acid change such as Y145del, Q414E, N439K, G446V, K458N, I472V, A475V, T478I, V483I, F490L, and A831V, as well as the double amino acid changes including D614G+Q321L, D614G+I472V, D614G+A831V, D614G+A879S and
SARS_CoV_2 mutation literature information.
PMID: 
2021
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