ViMRT
}  
 
Home   
< Docs   

 SARS_CoV_2 mutation literature information.


  The basis of mink susceptibility to SARS-CoV-2 infection.
 PMID: 35396646       2022       Journal of applied genetics
Figure: Boxes indicate substitutions (S32F, L50S, I76T, P218Q, D324E, T346R, T372A, T403R, K439N, H440N, I441L, A443S, E445V, F449Y, A459S, K478T, Q483V, T484E, L486F, Y490F, Y493Q, R494S, Y498Q


  Spike residue 403 affects binding of coronavirus spikes to human ACE2.
 PMID: 34824253       2021       Nature communications
Result: The T403R change in RaTG13 S, however, specifically enhanced ACE2 binding without affecting S expression levels.
Result: The WT SARS-CoV-2 and the T403R RaTG13 S proteins allowed efficient entry into cells overexpressing human ACE2, while the parental RaTG13 S protein was poorly active.
Result: The WT and T403A RaTG13 S were unable to complement SCoV-2DeltaS, while the T403R RaTG13 S resulted in significant CPE.



Browser Board

 Co-occurred Entities




   Filtrator