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 SARS_CoV_2 mutation literature information.


  The basis of mink susceptibility to SARS-CoV-2 infection.
 PMID: 35396646       2022       Journal of applied genetics
Figure: Boxes indicate substitutions (S32F, L50S, I76T, P218Q, D324E, T346R, T372A, T403R, K439N, H440N, I441L, A443S, E445V, F449Y, A459S, K478T, Q483V, T484E, L486F, Y490F, Y493Q, R494S, Y498Q


  A selective sweep in the Spike gene has driven SARS-CoV-2 human adaptation.
 PMID: 34289344       2021       Cell
Abstract: As predicted, T372A RBD bound hACE2 with higher affinity in experimental binding assays.
Abstract: We scanned more than 182,000 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genomes for selective sweep signatures and found a distinct footprint of positive selection located around a non-synonymous change (A1114G; T372A) within the spike protein receptor-binding domain (RBD), predicted to remove glycosylation and increase binding to human ACE2 (hACE2), the cellular receptor.
Result: Here we sought to define the effect of the S T372A mutation on viral replication in human cells.



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