Result: Type S was detected during the early period of the outbreak, and it has nucleotide substitutions at position 8,782 in ORF1ab (C8782T) and 28,144 (T28144C) in ORF8.
Geographical Distribution of Genetic Variants and Lineages of SARS-CoV-2 in Chile.
Discussion: At the beginning of the outbreak, Chinese isolates were mainly variant O, the most related to the reference sequence NC_045512.2, but in mid-January 2020, variant S (T 28144 C) and few cases of V (G 26144 T) and G (A 23403 G) started to appear.
Genomic exploration light on multiple origin with potential parsimony-informative sites of the severe acute respiratory syndrome coronavirus 2 in Bangladesh.
Discussion: In another study by, the most common variants were reported in ORF1ab (C8782T), ORF8 (T28144C) and N gene (C29095T).
Decoding Asymptomatic COVID-19 Infection and Transmission.
PMID: 33179934
2020
The journal of physical chemistry letters
Introduction: Mutation 11083G>T was also detected in a commutation record [8782C>T, 11083G>T, 28144T>C] in Yunnan, China 1 day earlier than Chongqing's sequence, which indicates that the true ancestor of 11083G>T might have occurred earlier than January 18, 2020.
Introduction: Mutation 11083G>T-(L37F) first appeared in the United States on January 22, 2020 in Arizona in a 26-year-old male with comutations [8782C>T, 11083G>T, 28144T>C, 29095C>T], which is the descendant of [8782C>T, 11083G>T,
Analysis of genomic distributions of SARS-CoV-2 reveals a dominant strain type with strong allelic associations.
Result: For example, in type II signature SNVs C8782T and T28144C that were also used to define the S and L type of SARS-CoV-2, these two SNVs (i.e., S type) first coappeared in strain MT291826 on December 30, 2019, and the coefficient of allelic association is R2 = 0.987.
Analysis of Indian SARS-CoV-2 Genomes Reveals Prevalence of D614G Mutation in Spike Protein Predicting an Increase in Interaction With TMPRSS2 and Virus Infectivity.
Method: We have used Nextstrain year-letter clade nomenclature that started with 19A and 19B branched by C8782T and T28144C nucleotide changes and was initially prevalent in Asia during initial outbreak.
Result: Among the common variants, the most frequent mutations are 23403 A > G (D614G, S gene), 241 C > T (5' UTR), 14408 C > T ( Result: In clade 19B samples, we observed a very distinct ORF8 T > C mutation at 28144 position, two N gene mutations at positions 28326 and 28878 with some ORF1ab mutation in lower frequency (Figure 2C).
Spike protein D614G and RdRp P323L: the SARS-CoV-2 mutations associated with severity of COVID-19.
SARS_CoV_2 mutation literature information.
PMID: 
2020
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