Result: Both 8782C>T and 29095C>T are synonymous; however, 28144T>C causes amino acid to change L84S in ORF8.
Result: Notably, most of 8782C>T and 28144T>Cvariant substrains are found outside of Wuhan.
Table: 28144T>C
Discussion: It is notable that most of 8782C>T and 28144T>C variant substrains are found outside of Wuhan.
Discussion: Many researchers found the relationship between ORFs with COVID-19 i.e.8782C>T(ORF1ab) and 28144T>C ( PMID: 32793182
2020
Frontiers in microbiology
Table: T28144C
Characterizing SARS-CoV-2 mutations in the United States.
Result: In Cluster A, B, C, and D, the co-mutations with the highest number of descendants are [
Result: Mutation 28144T>C-(L84S), the first known mutation globally, has had a very unsteady trajectory.
Result: Notably, after analyzing 28726 complete genome sequences, none of them have mutations 28144T>C-(L84S) and 27964C>T-(S24L) happened simultaneously.
Result: Table 4 shows that the folding stability change of 28144T>C-(L84S) is -0.99 kcal/mol, indicating that ORF8 becomes unstable.
Result: The first top mutation recorded in the US was 28144T>C-(L84S), on January 19.
Genomic surveillance of Nevada patients revealed prevalence of unique SARS-CoV-2 variants bearing mutations in the RdRp gene.
Result: Clade 19A and 19B are defined by C8782T and T28144C, respectively.
Phylogeography of SARS-CoV-2 pandemic in Spain: a story of multiple introductions, micro-geographic stratification, founder effects, and super-spreaders.
Result: The InCoV139-March sequence (Genbank: MT252824) shares the canonical mutations (C8782T and T28144C) which define clade 19B and distinguish it from the original clade 19A, Wuhan-Hu-1 reference strain (Genbank: NC_045512.2).
Characterization of local SARS-CoV-2 isolates and pathogenicity in IFNAR(-/-) mice.
SARS_CoV_2 mutation literature information.
PMID: 
2021
Journal of virology
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