literature

SARS_CoV_2 mutation literature information.

Emergence of B.1.524(G) SARS-CoV-2 in Malaysia during the third COVID-19 epidemic wave.

PMID: 34764315 2021 Scientific reports

Result: Besides the GISAID clade S-specific genetic markers, C8782T and T28144C, there were no other shared mutations between these two samples.

Table: T28144C

A next generation sequencing (NGS) analysis to reveal genomic and proteomic mutation landscapes of SARS-CoV-2 in South Asia.

PMID: 34841355 2021 Current research in microbial sciences

Result: 3b) and mutation in the ORF8 gene (28144T > C) was found only in this age group.

Characterization of altered genomic landscape of SARS-CoV-2 variants isolated in Saudi Arabia in a comparative in silico study.

PMID: 34866979 2021 Saudi journal of biological sciences

Discussion: In alignment with our findings several reports showed that C3037T and C241T changes were the two most frequent mutations, followed by C14408T, A23403G, and T28144C (L84S, ORF8).

A Conservative Replacement in the Transmembrane Domain of SARS-CoV-2 ORF7a as a Putative Risk Factor in COVID-19.

PMID: 34943191 2021 Biology

Abstract: 9659 in ORF-10, 8782C > T in ORF-1ab, or 28144T > C in ORF-8, have been proposed for altering SARS-CoV-2 virulence and pathogenicity.

A global analysis of replacement of genetic variants of SARS-CoV-2 in association with containment capacity and changes in disease severity.

PMID: 33524589 2021 Clinical microbiology and infection

Method: With reference to GISAID, variants were assigned to four lineages: L (reference sequence, nucleotide T28144, ORF8 amino acid L84), S (nt T28144C, ORF8 aa L84S), V (nt G26144T, ORF3a aa G251V) and G* (nt A23403G, S gene aa D614G).

Mutational analysis of SARS-CoV-2 ORF8 during six months of COVID-19 pandemic.

PMID: 33490718 2021 Gene reports

Introduction: Single Nucleotide Variations (SNVs) in ORF8 at 28144T>C (251T>C, L84S) characterize the SARS-CoV-2 S clade, leading to divergence of phylogenetic group.

In silico comparative genomics of SARS-CoV-2 to determine the source and diversity of the pathogen in Bangladesh.

PMID: 33471859 2021 PloS one

Result: In addition, other co-evolving mutations found were (241C>T, 3037C>T, 14408C>T, 23403A>G), (28881G>A, 28882G>A, 28883G>C), (8782C>T, 28144T>C), (4444G>T, 8371G>T, 29403A>G).

Engineering a Reliable and Convenient SARS-CoV-2 Replicon System for Analysis of Viral RNA Synthesis and Screening of Antiviral Inhibitors.

PMID: 33468688 2021 mBio

Abstract: Some viral variations, such as 5'UTR-C241T and ORF8-(T28144C) L84S mutation, also exhibit their different impact upon viral replication.

SARS-CoV-2 genomic characterization and clinical manifestation of the COVID-19 outbreak in Uruguay.

PMID: 33306459 2021 Emerging microbes & infections

Discussion: Uruguayan clade S viruses are characterized by the key mutations T28144 C, causing the AA replacement L84S in ORF8, and C8782 T, in agreement with global clade S strains.

Genomic characterization of SARS-CoV-2 in Egypt.

PMID: 33262895 2021 Journal of advanced research

Discussion: 8782C > T(ORF1ab) and 28144 T > C (ORF8), has been identified among researchers in several genome databases.

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