literature

SARS_CoV_2 mutation literature information.

Characterization of SARS-CoV-2 different variants and related morbidity and mortality: a systematic review.

PMID: 34103090 2021 European journal of medical research

Table: T28144C

Discussion: In other words, the S variant (Type A) with two mutations at 8782C>T and 28144 T>C was mainly identified in East Asia.

Genome-wide analysis of SARS-CoV-2 strains circulating in Vietnam: Understanding the nature of the epidemic and role of the D614G mutation.

PMID: 34042186 2021 Journal of medical virology

Result: ORF8 had one missense mutation at position T28144C that led to an amino acid change from Leucine to Serine (L84S).

SARS-CoV-2 mutations: the biological trackway towards viral fitness.

PMID: 33928885 2021 Epidemiology and infection

Introduction: Cluster I includes 3037C>T; NSP3:F106F (non-structural protein3:F106F) and 14408C>T; RdRp:P323L, cluster II includes 3037C>T, 14408C>T and 23403A>G; S:D614G, cluster III includes 14408C>T, cluster IV includes 3037C>T, 14408C>T, 23403A>G, 28881G>A; N:R203K, 28882G>A

Genomic Variations in SARS-CoV-2 Genomes From Gujarat: Underlying Role of Variants in Disease Epidemiology.

PMID: 33815459 2021 Frontiers in genetics

Table: T28144C

Pan-India novel coronavirus SARS-CoV-2 genomics and global diversity analysis in spike protein.

PMID: 33758785 2021 Heliyon

Result: Clades are characterized as S (C8782T, T28144C, NS8-L84S), L (C241, C3037, A23403, C8782, G11083, G25563, G26144, T28144, G228882), V (NSP6-L37F, NS3-G251V), G (S-D614S), GH (S-D614S, NS3-Q57H), S (S-D614S, NG204R).

Whole-genome sequencing of SARS-CoV-2 reveals the detection of G614 variant in Pakistan.

PMID: 33755704 2021 PloS one

Result: According to GISAID clade nomenclature (https://www.gisaid.org/references/statements-clarifications/clade-and-lineage-nomenclature-aids-in-genomic-epidemiology-of-active-hcov-19-viruses/), Pakistani strains NIH-44905 and NIH-HAS001 belong to S clade having characteristic genetic markers C8782T, T28144

Result: The Pakistani S clade strains contained nine common SNPs (2461T>C, 8782C>T, 11230G>T, 24051A>C, 26313C>T, 28144T>C, 28167G>A, 28878G>A, and 29742G>A).

Table: 28144T>C

Neutralising antibody escape of SARS-CoV-2 spike protein: Risk assessment for antibody-based Covid-19 therapeutics and vaccines.

PMID: 33724631 2021 Reviews in medical virology

Table: T28144C

Analysis of SARS-CoV-2 mutations in the United States suggests presence of four substrains and novel variants.

PMID: 33589648 2021 Communications biology

Result: In Cluster A, B, C, and D, the co-mutations with the highest number of descendants are [241C>T, 3037C>T, 14408C>T, 23403A>G], [3037C>T, 14408C>T], [8782C>T, 18060C>T, 28144T>C], and [3037C>T, 14408C>T, 23403A>G] respectively.

Result: In contrast, the time evolution plot shows that the ratio of mutatio

Result: Mutation 28144T>C-(L84S), the first known mutation globally, has had a very unsteady trajectory.

Phylogenomics reveals viral sources, transmission, and potential superinfection in early-stage COVID-19 patients in Ontario, Canada.

PMID: 33580132 2021 Scientific reports

Discussion: Clustering of shared mutations identified two samples (S21 and S23) that belong to A.1 lineage characterized by two polymorphic sites at C8782T and T28144C.

SARS-CoV-2 mutation 614G creates an elastase cleavage site enhancing its spread in high AAT-deficient regions.

PMID: 33556558 2021 Infection, genetics and evolution

Table: T28144C

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