literature

SARS_CoV_2 mutation literature information.

SARS-CoV-2 outbreak in Iran: The dynamics of the epidemic and evidence on two independent introductions.

PMID: 33835709 2022 Transboundary and emerging diseases

Result: We thus focussed on variants located in spike protein of viral isolates from Iran and identified spike variants in 28 samples (53%), in which D614G and T22I were occurring at higher frequencies of 24.5% and 17%, respectively (Table 2).

Discussion: Monitoring the spike mutations in Iranian SARS-CoV-2 genomes revealed no novel mutations in this genomic region, while determined two commonly known mutations, T22I and D6

Discussion: While the T22I mutation is less frequent in other regions, the D614G variant is now the most prevalent mutation in COVID-19 pandemic (Ahmadpour et al., 2020; Korber et al., 2020; Mercatelli and Giorgi, 2020).

Comprehensive annotations of the mutational spectra of SARS-CoV-2 spike protein: a fast and accurate pipeline.

PMID: 32954666 2021 Transboundary and emerging diseases

Table: T22I

Temporal increase in D614G mutation of SARS-CoV-2 in the Middle East and North Africa.

PMID: 33495741 2021 Heliyon

Table: T22I

Spike protein mutational landscape in India during the complete lockdown phase: Could Muller's ratchet be a future game-changer for COVID-19?

PMID: 33905891 2021 Infection, genetics and evolution

Result: In this ancestor 2 clade, several variants (L5F, T22I, L54F, G261S, T572I, E583D, Q677H, A706S, H1083Q) indicated their stability in the population via mutating further, giving rise to additional variants.

Bioinformatics Analysis Unveils Certain Mutations Implicated in Spike Structure Damage and Ligand-Binding Site of Severe Acute Respiratory Syndrome Coronavirus 2.

PMID: 34121839 2021 Bioinformatics and biology insights

Result: As in Table 5, Threonine (T) changes to Isoleucine (I) at different positions such as T22I, T76I, T95I, T572I, T791I, and T827I; whereas Glutamine (Q) changed to Histidine (H) (QLA10116 and QKW92184).

Result: In addition, Threonine (T) can change to Isoleucine at 3 different positions T22I, T240I, and T676I.

Table: T22I

Emerging mutation in SARS-CoV-2 spike: Widening distribution over time in different geographic areas.

PMID: 34271250 2021 Biomedical journal

Result: In addition, there were mutation types that have more than one case such as in Asia, the mutations A829T (n = 3), P25L (n = 2), V367F (n = 2), R682Q (n = 2), S13I (n = 2), and T22I (n = 2) while the other types have just one case.

Table: T22I

Discussion: We found 17 mutation types of total sequences located within the NTD including T22I, P25L, T29I, Y38C, H49Y, S50L, F86S, T95I, E96G, S151G,

Mutational analysis in international isolates and drug repurposing against SARS-CoV-2 spike protein: molecular docking and simulation approach.

PMID: 34307771 2021 Virusdisease

Result: T22I mutation was observed in the USA, India, Germany, a

Result: The frequent mutations in different isolates are L5F, T22I, T29I, H49Y, L54F, V90F, S98F, S221L, S254F, V367F, A520S, T572I, D614G, H655Y, P809S, A879S, D936Y, A1020S, A1078S, and H1101Y.

Bioinformatic analysis of the whole genome sequences of SARS-CoV-2 from Indonesia.

PMID: 34540148 2021 Iranian journal of microbiology

Table: T22I

Emergence of B.1.524(G) SARS-CoV-2 in Malaysia during the third COVID-19 epidemic wave.

PMID: 34764315 2021 Scientific reports

Table: T22I

SARS-CoV-2 lineage B.6 was the major contributor to early pandemic transmission in Malaysia.

PMID: 33253226 2020 PLoS neglected tropical diseases

Result: A secondary cluster within this healthcare-associated cluster contained six sequences with an additional mutation C21627T (T22I) in the spike protein.

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