literature

SARS_CoV_2 mutation literature information.

Glycan Masking of Epitopes in the NTD and RBD of the Spike Protein Elicits Broadly Neutralizing Antibodies Against SARS-CoV-2 Variants.

PMID: 34925381 2021 Frontiers in immunology

Introduction: The Gamma P.1 variant encodes an S protein with 12 mutations (L18F, T20N, P26S, D138Y, R190S, K417N/T, E484K, N501Y, D614G, H655Y, T1027I, and V1176F), two of which are in the RBD (E484K, and N501Y).

The Development of SARS-CoV-2 Variants: The Gene Makes the Disease.

PMID: 34940505 2021 Journal of developmental biology

Introduction: Still, it has been suggested that the great variability in the NTD between these variants, with allosteric influences from other mutations (T20N, P26S, D138Y, R190S; Table 2), could contribute to the observed differences.

Modelling conformational state dynamics and its role on infection for SARS-CoV-2 Spike protein variants.

PMID: 34351895 2021 PLoS computational biology

Result: P.1 variant includes the mutations L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, D614G, H655Y, T1027I.

Genomics and epidemiology of a novel SARS-CoV-2 lineage in Manaus, Brazil.

PMID: 33688664 2021 medRxiv

Introduction: Lineage P.1 contains 10 new amino acid mutations in the virus spike protein (L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, H655Y, T1027I) compared its immediate ancestor (B.1.1.28).

Neutralising antibody escape of SARS-CoV-2 spike protein: Risk assessment for antibody-based Covid-19 therapeutics and vaccines.

PMID: 33724631 2021 Reviews in medical virology

Table: T20N

Evidence of escape of SARS-CoV-2 variant B.1.351 from natural and vaccine-induced sera.

PMID: 33730597 2021 Cell

Result: Although P.1 does not harbor NTD deletions, the changes L18F, T20N, and P26S would be expected to impact markedly on binding at the NTD epitope.

Antibody evasion by the P.1 strain of SARS-CoV-2.

PMID: 33852911 2021 Cell

Result: Although P.1 does not harbor

Result: Compared to the Wuhan sequence, P.1 contains the following mutations: L18F, T20N, P26S, D138Y, and R190S in the NTD; K417T, E484K, and N501Y in the RBD; D614G and H655Y at the C terminus of S1; and T1027I and V1176F in S2.

Result: Of note, two of the NTD changes in P.1 introduce N-linked glycosylation sequons T20N (residues TRT to NRT) and R190S (residues NLR to NLS; Figure 1E).

Genomics and epidemiology of the P.1 SARS-CoV-2 lineage in Manaus, Brazil.

PMID: 33853970 2021 Science (New York, N.Y.)

Introduction: Lineage P.1 contains 10 lineage-defining amino acid mutations in the virus spike protein (L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, H655Y, and T1027I) compared with its immediate ancestor (B.1.1.28).

The Genetic Variant of SARS-CoV-2: would It Matter for Controlling the Devastating Pandemic?

PMID: 33907511 2021 International journal of biological sciences

Introduction: Except D614G, all the critical variants we reviewed here contain mutations in NTD: for example, L18F in variant 501.V2 and P.1, T20N and P26N in variant P.1, DeltaH69/DeltaV70 in Cluster 5 and VOC 202012/01, Y144 deletion in VOC 202012/01, 242-244 deletion and R246I in VOC 202012/01.

Impact of meteorological parameters and population density on variants of SARS-CoV-2 and outcome of COVID-19 pandemic in Japan.

PMID: 33908339 2021 Epidemiology and infection

Table: T20N

Browser Board

Co-occurred Entities

Filtrator